000208115 001__ 208115
000208115 005__ 20180913063121.0
000208115 0247_ $$2doi$$a10.1016/j.tibs.2015.03.003
000208115 022__ $$a0968-0004
000208115 02470 $$2ISI$$a000354143900006
000208115 037__ $$aARTICLE
000208115 245__ $$aNo DDRama at chromosome ends: TRF2 takes centre stage
000208115 260__ $$aLondon$$bElsevier Science London$$c2015
000208115 269__ $$a2015
000208115 300__ $$a11
000208115 336__ $$aReviews
000208115 520__ $$aTelomeres are nucleoprotein structures capping the natural termini of eukaryotic linear chromosomes. Telomeres possess an inherent ability to circumvent the activation of a full-blown DNA damage response (DDR), and hence fusion reactions, by limiting inappropriate double-strand break (DSB) repair and processing activities at eukaryotic chromosome ends. A telomere-specific protein complex, termed shelterin, has a crucial function in safeguarding and securing telomere integrity. Within this complex, TRF2 has emerged as the key player, dictating different states of telomere protection during the replicative lifespan of a cell. How TRF2 prevents activation of DSB repair activities at functional telomeres has now been extensively investigated. In this review we aim at exploring the complex and multifaceted mechanisms underlying the TRF2-mediated protection of eukaryotic chromosome ends.
000208115 6531_ $$aTRF2
000208115 6531_ $$atelomeres
000208115 6531_ $$aDNA damage response
000208115 6531_ $$achromatin
000208115 6531_ $$aTERRA
000208115 6531_ $$at-loops
000208115 700__ $$0243152$$aFeuerhahn, Sascha$$g185884$$uEcole Polytech Fed Lausanne, Sch Life Sci, Swiss Inst Expt Canc Res ISREC, CH-1015 Lausanne, Switzerland
000208115 700__ $$0243154$$aChen, Liuh-Yow$$g191071
000208115 700__ $$aLuke, Brian
000208115 700__ $$0243150$$aPorro, Antonio$$g184182$$uEcole Polytech Fed Lausanne, Sch Life Sci, Swiss Inst Expt Canc Res ISREC, CH-1015 Lausanne, Switzerland
000208115 773__ $$j40$$k5$$q275-285$$tTrends In Biochemical Sciences
000208115 909C0 $$0252450$$pISREC$$xU11153
000208115 909CO $$ooai:infoscience.tind.io:208115$$pSV$$preview
000208115 937__ $$aEPFL-REVIEW-208115
000208115 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000208115 980__ $$aREVIEW