The talk will discuss the challenges and a roadmap for digital business innovation for entrepreneurs as well as enterprises. Actually, digital business innovation requires a change of perspective with regard to IT governance and the management of IT infrastructure. This is due to the need to adapt them to the constant evolution and changes in business models, consequent to the digitalization of a company products and services. In particular, the talk will discuss the characteristics of four key types of digital business organisation, resulting from their orientation towards execution or else differentiation. Also, the talk will consider the business models fitting each specific type, showing as well their mapping to a company value chain. The talk is based on insights from the FutureEnterprise project, which aims to deliver a research roadmap on new forms of internet-based enterprise innovation. The focus of the project is on what are defined there as enterprises of the future, that are driven by constant business model transformation and innovation, acting as multi-sided platforms built on - as well as emerging from - digital innovations at the global as well as local level to produce shared value including that beyond monetization.