Genome-wide re-sequencing of multidrug-resistant Mycobacterium leprae Airaku-3
Singh, P.; Benjak, A.; Carat, S.; Kai, M.; Busso, P.; Avanzi, C.; Paniz-Mondolfi, A.; Peter, C.; Harshman, K.; Rougemont, J.; Matsuoka, M.; Cole, S. T.
2014

Abstract

Genotyping and molecular characterization of drug resistance mechanisms in Mycobacterium leprae enables disease transmission and drug resistance trends to be monitored. In the present study, we performed genome-wide analysis of Airaku-3, a multidrug-resistant strain with an unknown mechanism of resistance to rifampicin. We identified 12 unique non-synonymous single-nucleotide polymorphisms (SNPs) including two in the transporter-encoding ctpC and ctpI genes. In addition, two SNPs were found that improve the resolution of SNP-based genotyping, particularly for Venezuelan and South East Asian strains of M.leprae.

Details

Title Genome-wide re-sequencing of multidrug-resistant Mycobacterium leprae Airaku-3
Author(s) Singh, P. ; Benjak, A. ; Carat, S. ; Kai, M. ; Busso, P. ; Avanzi, C. ; Paniz-Mondolfi, A. ; Peter, C. ; Harshman, K. ; Rougemont, J. ; Matsuoka, M. ; Cole, S. T.
Published in Clinical Microbiology And Infection
Pagination 4
Volume 20
Issue 10
Pages O619-O622
Date 2014
Publisher Hoboken, Wiley-Blackwell
ISSN 1198-743X
Keywords
DOI https://doi.org/10.1111/1469-0691.12609
Other identifier(s) View record in Web of Science
Laboratories UPCOL
BICC
Record Appears in Scientific production and competences > SV - School of Life Sciences > PTECH - Core Facility > BICC - Bioinformatics Competence Center
Scientific production and competences > SV - School of Life Sciences > SV Archives > UPCOL - Prof. Cole Group
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2015-02-20

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