000205737 001__ 205737
000205737 005__ 20181203023804.0
000205737 0247_ $$2doi$$a10.1111/1469-0691.12609
000205737 022__ $$a1198-743X
000205737 02470 $$2ISI$$a000345825900006
000205737 037__ $$aARTICLE
000205737 245__ $$aGenome-wide re-sequencing of multidrug-resistant Mycobacterium leprae Airaku-3
000205737 260__ $$bWiley-Blackwell$$c2014$$aHoboken
000205737 269__ $$a2014
000205737 300__ $$a4
000205737 336__ $$aJournal Articles
000205737 520__ $$aGenotyping and molecular characterization of drug resistance mechanisms in Mycobacterium leprae enables disease transmission and drug resistance trends to be monitored. In the present study, we performed genome-wide analysis of Airaku-3, a multidrug-resistant strain with an unknown mechanism of resistance to rifampicin. We identified 12 unique non-synonymous single-nucleotide polymorphisms (SNPs) including two in the transporter-encoding ctpC and ctpI genes. In addition, two SNPs were found that improve the resolution of SNP-based genotyping, particularly for Venezuelan and South East Asian strains of M.leprae.
000205737 6531_ $$aLeprosy
000205737 6531_ $$amolecular epidemiology
000205737 6531_ $$aMycobacterium leprae
000205737 6531_ $$arifampicin-resistance
000205737 6531_ $$asingle nucleotide polymorphism
000205737 700__ $$uEcole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland$$aSingh, P.
000205737 700__ $$0243892$$g177247$$uEcole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland$$aBenjak, A.
000205737 700__ $$uEcole Polytech Fed Lausanne, Bioinformat & Biostat Core Facil, CH-1015 Lausanne, Switzerland$$aCarat, S.
000205737 700__ $$uNatl Inst Infect Dis, Leprosy Res Ctr, Tokyo, Japan$$aKai, M.
000205737 700__ $$uEcole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland$$aBusso, P.
000205737 700__ $$uEcole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland$$aAvanzi, C.
000205737 700__ $$uInst Biomed, Dept Biochem, Caracas, Venezuela$$aPaniz-Mondolfi, A.
000205737 700__ $$aPeter, C.
000205737 700__ $$aHarshman, K.
000205737 700__ $$uEcole Polytech Fed Lausanne, Bioinformat & Biostat Core Facil, CH-1015 Lausanne, Switzerland$$aRougemont, J.
000205737 700__ $$uNatl Inst Infect Dis, Leprosy Res Ctr, Tokyo, Japan$$aMatsuoka, M.
000205737 700__ $$uEcole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland$$aCole, S. T.$$g177247$$0243892
000205737 773__ $$j20$$tClinical Microbiology And Infection$$k10$$qO619-O622
000205737 909C0 $$xU11742$$0252302$$pUPCOL
000205737 909C0 $$xU12091$$0252538$$pPTBB
000205737 909CO $$pSV$$particle$$ooai:infoscience.tind.io:205737
000205737 917Z8 $$x217823
000205737 917Z8 $$x182396
000205737 937__ $$aEPFL-ARTICLE-205737
000205737 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000205737 980__ $$aARTICLE