Genome-wide re-sequencing of multidrug-resistant Mycobacterium leprae Airaku-3

Genotyping and molecular characterization of drug resistance mechanisms in Mycobacterium leprae enables disease transmission and drug resistance trends to be monitored. In the present study, we performed genome-wide analysis of Airaku-3, a multidrug-resistant strain with an unknown mechanism of resistance to rifampicin. We identified 12 unique non-synonymous single-nucleotide polymorphisms (SNPs) including two in the transporter-encoding ctpC and ctpI genes. In addition, two SNPs were found that improve the resolution of SNP-based genotyping, particularly for Venezuelan and South East Asian strains of M.leprae.


Published in:
Clinical Microbiology And Infection, 20, 10, O619-O622
Year:
2014
Publisher:
Hoboken, Wiley-Blackwell
ISSN:
1198-743X
Keywords:
Laboratories:




 Record created 2015-02-20, last modified 2018-09-13


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