000205721 001__ 205721
000205721 005__ 20180317092159.0
000205721 0247_ $$2doi$$a10.1021/nl503272r
000205721 022__ $$a1530-6984
000205721 02470 $$2ISI$$a000345723800091
000205721 037__ $$aARTICLE
000205721 245__ $$aMeasurement of the Position-Dependent Electrophoretic Force on DNA in a Glass Nanocapillary
000205721 260__ $$aWashington$$bAmerican Chemical Society$$c2014
000205721 269__ $$a2014
000205721 300__ $$a8
000205721 336__ $$aJournal Articles
000205721 520__ $$aThe electrophoretic force on a single DNA molecule inside a glass nanocapillary depends on the opening size and varies with the distance along the symmetrical axis of the nanocapillary. Using optical tweezers and DNA-coated beads, we measured the stalling forces and mapped the position-dependent force profiles acting on DNA inside nanocapillaries of different sizes. We showed that the stalling force is higher in nanocapillaries of smaller diameters. The position-dependent force profiles strongly depend on the size of the nanocapillary opening, and for openings smaller than 20 nm, the profiles resemble the behavior observed in solid-state nanopores. To characterize the position-dependent force profiles in nanocapillaries of different sizes, we used a model that combines information from both analytical approximations and numerical calculations.
000205721 6531_ $$aSingle molecule measurements
000205721 6531_ $$ananocapillary
000205721 6531_ $$asolid-state nanpore
000205721 6531_ $$aDNA translocation
000205721 6531_ $$aoptical tweezers
000205721 6531_ $$aforce measurements
000205721 700__ $$0246637$$aBulushev, Roman D.$$g225073$$uEcole Polytech Fed Lausanne, Sch Engn, Inst Bioengn, Lab Nanoscale Biol, CH-1015 Lausanne, Switzerland
000205721 700__ $$aSteinbock, Lorenz J.$$uEcole Polytech Fed Lausanne, Sch Engn, Inst Bioengn, Lab Nanoscale Biol, CH-1015 Lausanne, Switzerland
000205721 700__ $$aKhlybov, Sergey$$uEcole Polytech Fed Lausanne, Sch Engn, Inst Bioengn, Lab Nanoscale Biol, CH-1015 Lausanne, Switzerland
000205721 700__ $$aSteinbock, Julian F.$$uTech Univ Kaiserslautern, Fac Phys, D-67663 Kaiserslautern, Germany
000205721 700__ $$aKeyser, Ulrich F.
000205721 700__ $$0240208$$aRadenovic, Aleksandra$$g161458$$uEcole Polytech Fed Lausanne, Sch Engn, Inst Bioengn, Lab Nanoscale Biol, CH-1015 Lausanne, Switzerland
000205721 773__ $$j14$$k11$$q6606-6613$$tNano Letters
000205721 8564_ $$s2781131$$uhttps://infoscience.epfl.ch/record/205721/files/NanoLetters_Bulushev_2014.pdf$$yn/a$$zn/a
000205721 909CO $$ooai:infoscience.tind.io:205721$$particle$$pSTI
000205721 909C0 $$0252069$$pLBEN$$xU11842
000205721 917Z8 $$x161458
000205721 937__ $$aEPFL-ARTICLE-205721
000205721 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000205721 980__ $$aARTICLE