000205656 001__ 205656
000205656 005__ 20181203023801.0
000205656 0247_ $$2doi$$a10.1038/nbt.2960
000205656 022__ $$a1087-0156
000205656 02470 $$2ISI$$a000346455900019
000205656 037__ $$aARTICLE
000205656 245__ $$aOvercoming immunological barriers in regenerative medicine
000205656 269__ $$a2014
000205656 260__ $$bNature Publishing Group$$c2014$$aNew York
000205656 300__ $$a9
000205656 336__ $$aJournal Articles
000205656 520__ $$aRegenerative therapies that use allogeneic cells are likely to encounter immunological barriers similar to those that occur with transplantation of solid organs and allogeneic hematopoietic stem cells (HSCs). Decades of experience in clinical transplantation hold valuable lessons for regenerative medicine, offering approaches for developing tolerance-induction treatments relevant to cell therapies. Outside the field of solid-organ and allogeneic HSC transplantation, new strategies are emerging for controlling the immune response, such as methods based on biomaterials or mimicry of antigen-specific peripheral tolerance. Novel biomaterials can alter the behavior of cells in tissue-engineered constructs and can blunt host immune responses to cells and biomaterial scaffolds. Approaches to suppress autoreactive immune cells may also be useful in regenerative medicine. The most innovative solutions will be developed through closer collaboration among stem cell biologists, transplantation immunologists and materials scientists.
000205656 700__ $$uMem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10021 USA$$aZakrzewski, Johannes L.
000205656 700__ $$aVan Den Brink, Marcel R. M.
000205656 700__ $$g141360$$uEcole Polytech Fed Lausanne, Sch Life Sci, Inst Bioengn, Lausanne, Switzerland$$aHubbell, Jeffrey A.$$0240350
000205656 773__ $$j32$$tNature Biotechnology$$k8$$q786-794
000205656 909C0 $$0252196$$pLMRP$$xU11032
000205656 909CO $$particle$$ooai:infoscience.tind.io:205656
000205656 937__ $$aEPFL-ARTICLE-205656
000205656 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000205656 980__ $$aARTICLE