000205481 001__ 205481
000205481 005__ 20181203023755.0
000205481 0247_ $$2doi$$a10.1016/j.jorganchem.2014.10.003
000205481 022__ $$a0022-328X
000205481 02470 $$2ISI$$a000346049000012
000205481 037__ $$aARTICLE
000205481 245__ $$aEvaluation of the in vitro anticancer activity of cyclometalated half-sandwich rhodium and iridium complexes coordinated to naphthaldimine-based poly(propyleneimine) dendritic scaffolds
000205481 260__ $$aLausanne$$bElsevier Science Sa$$c2014
000205481 269__ $$a2014
000205481 300__ $$a7
000205481 336__ $$aJournal Articles
000205481 520__ $$aThe development of cyclometalated rhodium and iridium complexes from first-and second-generation naphthaldimine-based poly(propyleneimine) dendrimer scaffolds of the type, DAB-(NH2)(n) (where n = 4 or 8, DAB = diaminobutane) has been accomplished. Four metallodendrimers were synthesised, viz. (Cp*MCl)(4)G(n) (1-4), by first reacting DAB-(NH2)(n) with napththaldehyde and subsequently metallating the Schiff-base dendrimers with the dimers [Cp*MCl2](2) (where M = Rh or Ir). Related mononuclear complexes [Cp*MCl(L)] (L = naphthaldimine) (5-6) were obtained in a similar manner. The molecular structures of 5 and 6 have been determined by single-crystal X-ray diffraction analysis and the in vitro anticancer activities of 1-6 were evaluated against the A2780 and A2780cisR human ovarian carcinoma cell lines. (C) 2014 Elsevier B.V. All rights reserved.
000205481 6531_ $$aBioorganometallic chemistry
000205481 6531_ $$aCyclometalated
000205481 6531_ $$aRhodium
000205481 6531_ $$aIridium
000205481 6531_ $$aMetallodendrimers
000205481 6531_ $$aAnticancer drugs
000205481 700__ $$aSudding, Lara C.$$uUniv Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa
000205481 700__ $$aPayne, Richard$$uUniv Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa
000205481 700__ $$aGovender, Preshendren$$uUniv Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa
000205481 700__ $$0244412$$aEdafe, Fabio$$g196585$$uEcole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
000205481 700__ $$0244594$$aClavel, Catherine M.$$g192123$$uEcole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
000205481 700__ $$0240015$$aDyson, Paul J.$$g149418$$uEcole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
000205481 700__ $$aTherrien, Bruno
000205481 700__ $$aSmith, Gregory S.$$uUniv Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa
000205481 773__ $$j774$$q79-85$$tJournal Of Organometallic Chemistry
000205481 909C0 $$0252010$$pLCOM$$xU9
000205481 909CO $$ooai:infoscience.tind.io:205481$$pSB$$particle
000205481 917Z8 $$x240314
000205481 937__ $$aEPFL-ARTICLE-205481
000205481 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000205481 980__ $$aARTICLE