Synthesis, Structure, and Antiproliferative Activity of Ruthenium(II) Arene Complexes with N,O-Chelating Pyrazolone-Based beta-Ketoamine Ligands

Novel ruthenium half-sandwich complexes containing (N,O)-bound pyrazolone-based beta-ketoamine ligands have been prepared, and the solid-state structures of one ligand and five complexes have been determined by single-crystal X-ray diffraction. Some of the complexes display moderate cytotoxicity toward the human ovarian cancer cell lines A2780 and A2780cisR, the latter line having acquired resistance to cisplatin.


Publié dans:
Inorganic Chemistry, 53, 24, 13105-13111
Année
2014
Publisher:
Washington, Amer Chemical Soc
ISSN:
0020-1669
Laboratoires:




 Notice créée le 2015-02-20, modifiée le 2018-12-03


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