Gold finger formation studied by high-resolution mass spectrometry and in silico methods

High-resolution mass spectrometry and quantum mechanics/molecular mechanics studies were employed for characterizing the formation of two gold finger (GF) domains from the reaction of zinc fingers (ZF) with gold complexes. The influence of both the gold oxidation state and the ZF coordination sphere in GF formation provided useful insights into the possible design of new gold complexes targeting specific ZF motifs.


Published in:
Chemical Communications, 51, 9, 1612-1615
Year:
2015
Publisher:
Cambridge, Royal Soc Chemistry
ISSN:
1359-7345
Laboratories:




 Record created 2015-02-20, last modified 2018-03-17


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