We present a Boolean logic optimization framework based on Majority-Inverter Graph (MIG). An MIG is a directed acyclic graph consisting of three-input majority nodes and regular/complemented edges. Current MIG optimization is supported by a consistent algebraic framework. However, when algebraic methods cannot improve a result quality, stronger Boolean methods are needed to attain further optimization. For this purpose, we propose MIG Boolean methods exploiting the error masking property of majority operators. Our MIG Boolean methods insert logic errors that strongly simplify an MIG while being successively masked by the voting nature of majority nodes. Thanks to the datastructure/ methodology fitness, our MIG Boolean methods run in principle as fast as algebraic counterparts. Experiments show that our Boolean methodology combined with state-of-art MIG algebraic techniques enable superior optimization quality. For example, when targeting depth reduction, our MIG optimizer transforms a ripple carry adder into a carry look-ahead one. Considering the set of IWLS’05 (arithmetic intensive) benchmarks, our MIG optimizer reduces by 17.98% (26.69%) the logic network depth while also enhancing size and power activity metrics, with respect to ABC academic optimizer. Without MIG Boolean methods, i.e., using MIG algebraic optimization alone, the previous gains are halved. Employed as front-end to a delay-critical 22-nm ASIC flow (logic synthesis + physical design) our MIG optimizer reduces the average delay/area/power by (15.07%, 4.93%, 1.93%), over 27 academic and industrial benchmarks, as compared to a leading commercial ASIC flow.