Synaptic consolidation: from synapses to behavioral modeling

Synaptic plasticity, a key process for memory formation, manifests itself across different time scales ranging from a few seconds for plasticity induction up to hours or even years for consolidation and memory retention. We developed a three-layered model of synaptic consolidation that accounts for data across a large range of experimental conditions. Consolidation occurs in the model through the interaction of the synaptic efficacy with a scaffolding variable by a read-write process mediated by a tagging-related variable. Plasticity-inducing stimuli modify the efficacy, but the state of tag and scaffold can only change if a write protection mechanism is overcome. Our model makes a link from depotentiation protocols in vitro to behavioral results regarding the influence of novelty on inhibitory avoidance memory in rats.


Published in:
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35, 3, 1319-34
Year:
2015
Publisher:
Society for Neuroscience
ISSN:
1529-2401
Keywords:
Note:
funded by the Swiss National Science Foundation (SNSF) and the European community under ERC and Brainscales
This work was supported by the Swiss National Science Foundation (Grant 200020 13287, Coding Characteris- tics), the European Research Council (Grant 268689, MultiRules and European FP7 Grant 2269921, BrainScaleS). D.B.K. was supported by a Fulbright award in cooperation with a Swiss Government Scholarship.
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 Record created 2015-01-23, last modified 2018-12-03

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