000204651 001__ 204651
000204651 005__ 20190317000059.0
000204651 0247_ $$2doi$$a10.1109/JSEN.2014.2339638
000204651 022__ $$a1530-437X
000204651 02470 $$2ISI$$a000351220200016
000204651 037__ $$aARTICLE
000204651 245__ $$aA Subcutaneous Biochip for Remote Monitoring of Human Metabolism: Packaging and Biocompatibility Assessment
000204651 269__ $$a2015
000204651 260__ $$bInstitute of Electrical and Electronics Engineers$$c2015$$aPiscataway
000204651 300__ $$a8
000204651 336__ $$aJournal Articles
000204651 520__ $$aThis paper represents the extended version of the conference paper “Developing highly-integrated subcutaneous biochips for remote monitoring of human metabolism” pre- sented at the IEEE Sensors Conference 2012, and presents data on assembly, packaging and short term in vitro and in vivo biocompatibility evaluation of a fully implantable biosensor array. The device was realized integrating three building blocks: 1) a multielectrode platform; 2) an inductive coil; and 3) an integrated circuit. The entire system measures 2.2 mm × 2.2 mm × 15 mm. Corrosion of electronic components and leaking of potentially hazardous substances in the body is prevented with a conformal coating of Parylene C, while an outer package of medical grade silicone was employed to create a soft shell suitable for implantation. Biocompatibility experiments did not show in vitro cytotoxicity in the considered period of 7 days, while comparison between 7 and 30 days in vivo implantations showed significant reduction of the inflammatory response in time, suggesting normal host recovery.
000204651 6531_ $$abiosensors
000204651 6531_ $$aimplantable biomedical devices
000204651 6531_ $$aelectronics packaging
000204651 700__ $$0242421$$g176841$$aCavallini, Andrea
000204651 700__ $$aRezzonico Jost, Tanja
000204651 700__ $$0244626$$g200713$$aGhoreishizadeh, Seyedeh Sara
000204651 700__ $$0242419$$g183208$$aOlivo, Jacopo
000204651 700__ $$aOp de Beeck, Maaike
000204651 700__ $$aGorissen, Benjamin
000204651 700__ $$aGrassi, Fabio
000204651 700__ $$0240269$$g167918$$aDe Micheli, Giovanni
000204651 700__ $$g182237$$aCarrara, Sandro$$0242413
000204651 773__ $$j15$$tIEEE Sensors Journal$$k1$$q417-424
000204651 8564_ $$uhttps://infoscience.epfl.ch/record/204651/files/06860308.pdf$$zn/a$$s1692865$$yn/a
000204651 909C0 $$xU11140$$0252283$$pLSI1
000204651 909CO $$particle$$ooai:infoscience.tind.io:204651$$qGLOBAL_SET$$pSTI$$pIC
000204651 917Z8 $$x112915
000204651 937__ $$aEPFL-ARTICLE-204651
000204651 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000204651 980__ $$aARTICLE