Pd-Catalyzed Dehydrogenative Aryl−Aryl Bond Formation via Double C(sp2)−H Bond Activation: Efficient Synthesis of [3,4]-Fused Oxindoles
Bunescu, Ala; Piou, Tiffany; Wang, Qian; Zhu, Jieping
2015

Abstract

A Pd(0)-catalyzed double cyclization of easily available o-bromoanilides leading to strained [3,4]-fused oxindoles was developed. The reaction proceeded through a highly ordered sequence involving key carbopalladation, 1,4-Pd migration, and C(sp2)−H functionalization steps.

Details

Title Pd-Catalyzed Dehydrogenative Aryl−Aryl Bond Formation via Double C(sp2)−H Bond Activation: Efficient Synthesis of [3,4]-Fused Oxindoles
Author(s) Bunescu, Ala ; Piou, Tiffany ; Wang, Qian ; Zhu, Jieping
Published in Organic Letters
Volume 17
Issue 2
Pages 334-337
Date 2015
ISSN 1523-7052
DOI https://doi.org/10.1021/ol503442n
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Laboratories LSPN
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LSPN - Laboratory of synthesis and natural products
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2015-01-17