We show how large DNP enhancements of NMR signals can be obtained from several hydrophobic radicals that are solubilised in aqueous environments by a variety of biologically compatible neutral amphiphiles. In particular we show that the bi-radical TEKPOL can be incorporated into micelles formed by the surfactant polysorbate 80 (Tween-80), where we obtain large DNP enhancements (similar to 60) at 9.4 T and similar to 100 K.