000204180 001__ 204180
000204180 005__ 20180317091952.0
000204180 0247_ $$2doi$$a10.1016/j.coviro.2014.08.001
000204180 022__ $$a1879-6257
000204180 02470 $$2ISI$$a000343846400020
000204180 037__ $$aARTICLE
000204180 245__ $$aHuman cytomegalovirus intrahost evolution - a new avenue for understanding and controlling herpesvirus infections
000204180 260__ $$aOxford$$bElsevier Sci Ltd$$c2014
000204180 269__ $$a2014
000204180 300__ $$a7
000204180 336__ $$aJournal Articles
000204180 520__ $$aHuman cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on the order of days or months. We describe the intrahost genetic diversity of the virus isolated from humans, and how this diversity contributes to HCMV spatiotemporal evolution. We propose mechanisms to explain the high levels of intrahost diversity and discuss how this new information may shed light on HCMV infection and pathogenesis.
000204180 700__ $$aRenzette, Nicholas$$uUniv Massachusetts, Sch Med, Dept Microbiol & Physiol Syst, Worcester, MA 01655 USA
000204180 700__ $$aGibson, Laura$$uUniv Massachusetts, Sch Med, Dept Pediat, Worcester, MA 01655 USA
000204180 700__ $$0246317$$aJensen, Jeffrey D.$$g217758$$uUniv Massachusetts, Sch Med, Program Bioinformat & Integrat Biol, Worcester, MA 01655 USA
000204180 700__ $$aKowalik, Timothy F.$$uUniv Massachusetts, Sch Med, Dept Microbiol & Physiol Syst, Worcester, MA 01655 USA
000204180 773__ $$j8$$q109-115$$tCurrent Opinion In Virology
000204180 909CO $$ooai:infoscience.tind.io:204180$$particle$$pSV
000204180 909C0 $$0252425$$pUPJENSEN$$xU12516
000204180 937__ $$aEPFL-ARTICLE-204180
000204180 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000204180 980__ $$aARTICLE