Human cytomegalovirus intrahost evolution - a new avenue for understanding and controlling herpesvirus infections

Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on the order of days or months. We describe the intrahost genetic diversity of the virus isolated from humans, and how this diversity contributes to HCMV spatiotemporal evolution. We propose mechanisms to explain the high levels of intrahost diversity and discuss how this new information may shed light on HCMV infection and pathogenesis.


Published in:
Current Opinion In Virology, 8, 109-115
Year:
2014
Publisher:
Oxford, Elsevier Sci Ltd
ISSN:
1879-6257
Laboratories:




 Record created 2014-12-30, last modified 2018-03-17


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