Defining the role of common variation in the genomic and biological architecture of adult human height
Wood, Andrew R.; Esko, Tonu; Yang, Jian; Vedantam, Sailaja; Pers, Tune H.; Gustafsson, Stefan; Chun, Audrey Y.; Estrada, Karol; Luan, Jian'An; Kutalik, Zoltan; Amin, Najaf; Buchkovich, Martin L.; Croteau-Chonka, Damien C.; Day, Felix R.; Duan, Yanan; Fall, Tove; Fehrmann, Rudolf; Ferreira, Teresa; Jackson, Anne U.; Karjalainen, Juha; Lo, Ken Sin; Locke, Adam E.; Maegi, Reedik; Mihailov, Evelin; Porcu, Eleonora; Randall, Joshua C.; Scherag, Andre; Vinkhuyzen, Anna A. E.; Westra, Harm-Jan; Winkler, Thomas W.; Workalemahu, Tsegaselassie; Zhao, Jing Hua; Absher, Devin; Albrecht, Eva; Anderson, Denise; Baron, Jeffrey; Beekman, Marian; Demirkan, Ayse; Ehret, Georg B.; Feenstra, Bjarke; Feitosa, Mary F.; Fischer, Krista; Fraser, Ross M.; Goel, Anuj; Gong, Jian; Justice, Anne E.; Kanoni, Stavroula; Kleber, Marcus E.; Kristiansson, Kati; Lim, Unhee; Lotay, Vaneet; Lui, Julian C.; Mangino, Massimo; Leach, Irene Mateo; Medina-Gomez, Carolina; Nalls, Michael A.; Nyholt, Dale R.; Palmer, Cameron D.; Pasko, Dorota; Pechlivanis, Sonali; Prokopenko, Inga; Ried, Janina S.; Ripke, Stephan; Shungin, Dmitry; Stancakova, Alena; Strawbridge, Rona J.; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; Van Der Laan, Sander W.; Van Setten, Jessica; Van Vliet-Ostaptchouk, Jana V.; Wang, Zhaoming; Yengo, Loic; Zhang, Weihua; Afzal, Uzma; Arnloev, Johan; Arscott, Gillian M.; Bandinelli, Stefania; Barrett, Amy; Bellis, Claire; Bennett, Amanda J.; Berne, Christian; Blueher, Matthias; Bolton, Jennifer L.; Boettcher, Yvonne; Boyd, Heather A.; Bruinenberg, Marcel; Buckley, Brendan M.; Buyske, Steven; Caspersen, Ida H.; Chines, Peter S.; Clarke, Robert; Claudi-Boehm, Simone; Cooper, Matthew; Daw, E. Warwick; De Jong, Pim A.; Deelen, Joris; Delgado, Graciela; Denny, Josh C.; Dhonukshe-Rutten, Rosalie; Dimitriou, Maria; Doney, Alex S. F.; Doerr, Marcus; Eklund, Niina; Eury, Elodie; Folkersen, Lasse; Garcia, Melissa E.; Geller, Frank; Giedraitis, Vilmantas; Go, Alan S.; Grallert, Harald; Grammer, Tanja B.; Graessler, Juergen; Groenberg, Henrik; De Groot, Lisette C. P. G. M.; Groves, Christopher J.; Haessler, Jeffrey; Hall, Per; Haller, Toomas; Hallmans, Goran; Hannemann, Anke; Hartman, Catharina A.; Hassinen, Maija; Hayward, Caroline; Heard-Costa, Nancy L.; Helmer, Quinta; Hemani, Gibran; Henders, Anjali K.; Hillege, Hans L.; Hlatky, Mark A.; Hoffmann, Wolfgang; Hoffmann, Per; Holmen, Oddgeir; Houwing-Duistermaat, Jeanine J.; Illig, Thomas; Isaacs, Aaron; James, Alan L.; Jeff, Janina; Johansen, Bent; Johansson, Asa; Jolley, Jennifer; Juliusdottir, Thorhildur; Junttila, Juhani; Kho, Abel N.; Kinnunen, Leena; Klopp, Norman; Kocher, Thomas; Kratzer, Wolfgang; Lichtner, Peter; Lind, Lars; Lindstroem, Jaana; Lobbens, Stephane; Lorentzon, Mattias; Lu, Yingchang; Lyssenko, Valeriya; Magnusson, Patrik K. E.; Mahajan, Anubha; Maillard, Marc; Mcardle, Wendy L.; Mckenzie, Colin A.; Mclachlan, Stela; Mclaren, Paul J.; Menni, Cristina; Merger, Sigrun; Milani, Lili; Moayyeri, Alireza; Monda, Keri L.; Morken, Mario A.; Mueller, Gabriele; Mueller-Nurasyid, Martina; Musk, Arthur W.; Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M.; Noethen, Markus M.; Oozageer, Laticia; Pilz, Stefan; Rayner, Nigel W.; Renstrom, Frida; Robertson, Neil R.; Rose, Lynda M.; Roussel, Ronan; Sanna, Serena; Scharnagl, Hubert; Scholtens, Salome; Schumacher, Fredrick R.; Schunkert, Heribert; Scott, Robert A.; Sehmi, Joban; Seufferlein, Thomas; Shin, Jianxin; Silventoinen, Karri; Smit, Johannes H.; Smith, Albert Vernon; Smolonska, Joanna; Stanton, Alice V.; Stirrups, Kathleen; Stott, David J.; Stringham, Heather M.; Sundstrom, Johan; Swertz, Morris A.; Syvanen, Ann-Christine; Tayo, Bamidele O.; Thorleifsson, Gudmar; Tyrer, Jonathan P.; Van Dijk, Suzanne; Van Schoor, Natasja M.; Van Der Velde, Nathalie; Van Heemst, Diana; Van Oort, Floor V. A.; Vermeulen, Sita H.; Verweij, Niek; Vonk, Judith M.; Waite, Lindsay L.; Waldenberger, Melanie; Wennauer, Roman; Wilkens, Lynne R.; Willenborg, Christina; Wilsgaard, Tom; Wojczynski, Mary K.; Wong, Andrew; Wright, Alan F.; Zhang, Qunyuan; Arveiler, Dominique; Bakker, Stephan J. L.; Beilby, John; Bergman, Richard N.; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boomsma, Dorret I.; Bornstein, Stefan R.; Bovet, Pascal; Brambilla, Paolo; Brown, Morris J.; Campbell, Harry; Caulfield, Mark J.; Chakravarti, Aravinda; Collins, Rory; Collins, Francis S.; Crawford, Dana C.; Cupples, L. Adrienne; Danesh, John; De Faire, Ulf; Den Ruijter, Hester M.; Erbel, Raimund; Erdmann, Jeanette; Eriksson, Johan G.; Farrall, Martin; Ferrannini, Ele; Ferrieres, Jean; Ford, Ian; Forouhi, Nita G.; Forrester, Terrence; Gansevoort, Ron T.; Gejman, Pablo V.; Gieger, Christian; Golay, Alain; Gottesman, Omri; Gudnason, Vilmundur; Gyllensten, Ulf; Haas, David W.; Hall, Alistair S.; Harris, Tamara B.; Hattersley, Andrew T.; Heath, Andrew C.; Hengstenberg, Christian; Hicks, Andrew A.; Hindorff, Lucia A.; Hingorani, Aroon D.; Hofman, Albert; Hovingh, G. Kees; Humphries, Steve E.; Hunt, Steven C.; Hypponen, Elina; Jacobs, Kevin B.; Jarvelin, Marjo-Riitta; Jousilahti, Pekka; Jula, Antti M.; Kaprio, Jaakko; Kastelein, John J. P.; Kayser, Manfred; Kee, Frank; Keinanen-Kiukaanniemi, Sirkka M.; Kiemeney, Lambertus A.; Kooner, Jaspal S.; Kooperberg, Charles; Koskinen, Seppo; Kovacs, Peter; Kraja, Aldi T.; Kumari, Meena; Kuusisto, Johanna; Lakka, Timo A.; Langenberg, Claudia; Le Marchand, Loic; Lehtimaki, Terho; Lupoli, Sara; Madden, Pamela A. F.; Mannisto, Satu; Manunta, Paolo; Marette, Andre; Matise, Tara C.; Mcknight, Barbara; Meitinger, Thomas; Moll, Frans L.; Montgomery, Grant W.; Morris, Andrew D.; Morris, Andrew P.; Murray, Jeffrey C.; Nelis, Mari; Ohlsson, Claes; Oldehinkel, Albertine J.; Ong, Ken K.; Ouwehand, Willem H.; Pasterkamp, Gerard; Peters, Annette; Pramstaller, Peter P.; Price, Jackie F.; Qi, Lu; Raitakari, Olli T.; Rankinen, Tuomo; Rao, D. C.; Rice, Treva K.; Ritchie, Marylyn; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J.; Saramies, Jouko; Sarzynski, Mark A.; Schwarz, Peter E. H.; Sebert, Sylvain; Sever, Peter; Shuldiner, Alan R.; Sinisalo, Juha; Steinthorsdottir, Valgerdur; Stolk, Ronald P.; Tardif, Jean-Claude; Toenjes, Anke; Tremblay, Angelo; Tremoli, Elena; Virtamo, Jarmo; Vohl, Marie-Claude; Amouyel, Philippe; Asselbergs, Folkert W.; Assimes, Themistocles L.; Bochud, Murielle; Boehm, Bernhard O.; Boerwinkle, Eric; Bottinger, Erwin P.; Bouchard, Claude; Cauchi, Stephane; Chambers, John C.; Chanock, Stephen J.; Cooper, Richard S.; De Bakker, Paul I. W.; Dedoussis, George; Ferrucci, Luigi; Franks, Paul W.; Froguel, Philippe; Groop, Leif C.; Haiman, Christopher A.; Hamsten, Anders; Hayes, M. Geoffrey; Hui, Jennie; Hunter, David J.; Hveem, Kristian; Jukema, J. Wouter; Kaplan, Robert C.; Kivimaki, Mika; Kuh, Diana; Laakso, Markku; Liu, Yongmei; Martin, Nicholas G.; Maerz, Winfried; Melbye, Mads; Moebus, Susanne; Munroe, Patricia B.; Njolstad, Inger; Oostra, Ben A.; Palmer, Colin N. A.; Pedersen, Nancy L.; Perola, Markus; Perusse, Louis; Peters, Ulrike; Powell, Joseph E.; Power, Chris; Quertermous, Thomas; Rauramaa, Rainer; Reinmaa, Eva; Ridker, Paul M.; Rivadeneira, Fernando; Rotter, Jerome I.; Saaristo, Timo E.; Saleheen, Danish; Schlessinger, David; Slagboom, P. Eline; Snieder, Harold; Spector, Tim D.; Strauch, Konstantin; Stumvoll, Michael; Tuomilehto, Jaakko; Uusitupa, Matti; Van Der Harst, Pim; Voelzke, Henry; Walker, Mark; Wareham, Nicholas J.; Watkins, Hugh; Wichmann, H-Erich; Wilson, James F.; Zanen, Pieter; Deloukas, Panos; Heid, Iris M.; Lindgren, Cecilia M.; Mohlke, Karen L.; Speliotes, Elizabeth K.; Thorsteinsdottir, Unnur; Barroso, Ines; Fox, Caroline S.; North, Kari E.; Strachan, David P.; Beckmann, Jacques S.; Berndt, Sonja I.; Boehnke, Michael; Borecki, Ingrid B.; Mccarthy, Mark I.; Metspalu, Andres; Stefansson, Kari; Uitterlinden, Andre G.; Van Duijn, Cornelia M.; Franke, Lude; Willer, Cristen J.; Price, Alkes L.; Lettre, Guillaume; Loos, Ruth J. F.; Weedon, Michael N.; Ingelsson, Erik; O'Connell, Jeffrey R.; Abecasis, Goncalo R.; Chasman, Daniel I.; Goddard, Michael E.; Visscher, Peter M.; Hirschhorn, Joel N.; Frayling, Timothy M.; Elect Med Records & Genom eMERGE C; MIGen Consortium; PAGE Consortium; LifeLines Cohort Study
2014
Abstract
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated similar to 2,000, similar to 3,700 and similar to 9,500 SNPs explained similar to 21%, similar to 24% and similar to 29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/beta-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
Details
Title
Defining the role of common variation in the genomic and biological architecture of adult human height
Author(s)
Wood, Andrew R. ; Esko, Tonu ; Yang, Jian ; Vedantam, Sailaja ; Pers, Tune H. ; Gustafsson, Stefan ; Chun, Audrey Y. ; Estrada, Karol ; Luan, Jian'An ; Kutalik, Zoltan ; Amin, Najaf ; Buchkovich, Martin L. ; Croteau-Chonka, Damien C. ; Day, Felix R. ; Duan, Yanan ; Fall, Tove ; Fehrmann, Rudolf ; Ferreira, Teresa ; Jackson, Anne U. ; Karjalainen, Juha ; Lo, Ken Sin ; Locke, Adam E. ; Maegi, Reedik ; Mihailov, Evelin ; Porcu, Eleonora ; Randall, Joshua C. ; Scherag, Andre ; Vinkhuyzen, Anna A. E. ; Westra, Harm-Jan ; Winkler, Thomas W. ; Workalemahu, Tsegaselassie ; Zhao, Jing Hua ; Absher, Devin ; Albrecht, Eva ; Anderson, Denise ; Baron, Jeffrey ; Beekman, Marian ; Demirkan, Ayse ; Ehret, Georg B. ; Feenstra, Bjarke ; Feitosa, Mary F. ; Fischer, Krista ; Fraser, Ross M. ; Goel, Anuj ; Gong, Jian ; Justice, Anne E. ; Kanoni, Stavroula ; Kleber, Marcus E. ; Kristiansson, Kati ; Lim, Unhee ; Lotay, Vaneet ; Lui, Julian C. ; Mangino, Massimo ; Leach, Irene Mateo ; Medina-Gomez, Carolina ; Nalls, Michael A. ; Nyholt, Dale R. ; Palmer, Cameron D. ; Pasko, Dorota ; Pechlivanis, Sonali ; Prokopenko, Inga ; Ried, Janina S. ; Ripke, Stephan ; Shungin, Dmitry ; Stancakova, Alena ; Strawbridge, Rona J. ; Sung, Yun Ju ; Tanaka, Toshiko ; Teumer, Alexander ; Trompet, Stella ; Van Der Laan, Sander W. ; Van Setten, Jessica ; Van Vliet-Ostaptchouk, Jana V. ; Wang, Zhaoming ; Yengo, Loic ; Zhang, Weihua ; Afzal, Uzma ; Arnloev, Johan ; Arscott, Gillian M. ; Bandinelli, Stefania ; Barrett, Amy ; Bellis, Claire ; Bennett, Amanda J. ; Berne, Christian ; Blueher, Matthias ; Bolton, Jennifer L. ; Boettcher, Yvonne ; Boyd, Heather A. ; Bruinenberg, Marcel ; Buckley, Brendan M. ; Buyske, Steven ; Caspersen, Ida H. ; Chines, Peter S. ; Clarke, Robert ; Claudi-Boehm, Simone ; Cooper, Matthew ; Daw, E. Warwick ; De Jong, Pim A. ; Deelen, Joris ; Delgado, Graciela ; Denny, Josh C. ; Dhonukshe-Rutten, Rosalie ; Dimitriou, Maria ; Doney, Alex S. F. ; Doerr, Marcus ; Eklund, Niina ; Eury, Elodie ; Folkersen, Lasse ; Garcia, Melissa E. ; Geller, Frank ; Giedraitis, Vilmantas ; Go, Alan S. ; Grallert, Harald ; Grammer, Tanja B. ; Graessler, Juergen ; Groenberg, Henrik ; De Groot, Lisette C. P. G. M. ; Groves, Christopher J. ; Haessler, Jeffrey ; Hall, Per ; Haller, Toomas ; Hallmans, Goran ; Hannemann, Anke ; Hartman, Catharina A. ; Hassinen, Maija ; Hayward, Caroline ; Heard-Costa, Nancy L. ; Helmer, Quinta ; Hemani, Gibran ; Henders, Anjali K. ; Hillege, Hans L. ; Hlatky, Mark A. ; Hoffmann, Wolfgang ; Hoffmann, Per ; Holmen, Oddgeir ; Houwing-Duistermaat, Jeanine J. ; Illig, Thomas ; Isaacs, Aaron ; James, Alan L. ; Jeff, Janina ; Johansen, Bent ; Johansson, Asa ; Jolley, Jennifer ; Juliusdottir, Thorhildur ; Junttila, Juhani ; Kho, Abel N. ; Kinnunen, Leena ; Klopp, Norman ; Kocher, Thomas ; Kratzer, Wolfgang ; Lichtner, Peter ; Lind, Lars ; Lindstroem, Jaana ; Lobbens, Stephane ; Lorentzon, Mattias ; Lu, Yingchang ; Lyssenko, Valeriya ; Magnusson, Patrik K. E. ; Mahajan, Anubha ; Maillard, Marc ; Mcardle, Wendy L. ; Mckenzie, Colin A. ; Mclachlan, Stela ; Mclaren, Paul J. ; Menni, Cristina ; Merger, Sigrun ; Milani, Lili ; Moayyeri, Alireza ; Monda, Keri L. ; Morken, Mario A. ; Mueller, Gabriele ; Mueller-Nurasyid, Martina ; Musk, Arthur W. ; Narisu, Narisu ; Nauck, Matthias ; Nolte, Ilja M. ; Noethen, Markus M. ; Oozageer, Laticia ; Pilz, Stefan ; Rayner, Nigel W. ; Renstrom, Frida ; Robertson, Neil R. ; Rose, Lynda M. ; Roussel, Ronan ; Sanna, Serena ; Scharnagl, Hubert ; Scholtens, Salome ; Schumacher, Fredrick R. ; Schunkert, Heribert ; Scott, Robert A. ; Sehmi, Joban ; Seufferlein, Thomas ; Shin, Jianxin ; Silventoinen, Karri ; Smit, Johannes H. ; Smith, Albert Vernon ; Smolonska, Joanna ; Stanton, Alice V. ; Stirrups, Kathleen ; Stott, David J. ; Stringham, Heather M. ; Sundstrom, Johan ; Swertz, Morris A. ; Syvanen, Ann-Christine ; Tayo, Bamidele O. ; Thorleifsson, Gudmar ; Tyrer, Jonathan P. ; Van Dijk, Suzanne ; Van Schoor, Natasja M. ; Van Der Velde, Nathalie ; Van Heemst, Diana ; Van Oort, Floor V. A. ; Vermeulen, Sita H. ; Verweij, Niek ; Vonk, Judith M. ; Waite, Lindsay L. ; Waldenberger, Melanie ; Wennauer, Roman ; Wilkens, Lynne R. ; Willenborg, Christina ; Wilsgaard, Tom ; Wojczynski, Mary K. ; Wong, Andrew ; Wright, Alan F. ; Zhang, Qunyuan ; Arveiler, Dominique ; Bakker, Stephan J. L. ; Beilby, John ; Bergman, Richard N. ; Bergmann, Sven ; Biffar, Reiner ; Blangero, John ; Boomsma, Dorret I. ; Bornstein, Stefan R. ; Bovet, Pascal ; Brambilla, Paolo ; Brown, Morris J. ; Campbell, Harry ; Caulfield, Mark J. ; Chakravarti, Aravinda ; Collins, Rory ; Collins, Francis S. ; Crawford, Dana C. ; Cupples, L. Adrienne ; Danesh, John ; De Faire, Ulf ; Den Ruijter, Hester M. ; Erbel, Raimund ; Erdmann, Jeanette ; Eriksson, Johan G. ; Farrall, Martin ; Ferrannini, Ele ; Ferrieres, Jean ; Ford, Ian ; Forouhi, Nita G. ; Forrester, Terrence ; Gansevoort, Ron T. ; Gejman, Pablo V. ; Gieger, Christian ; Golay, Alain ; Gottesman, Omri ; Gudnason, Vilmundur ; Gyllensten, Ulf ; Haas, David W. ; Hall, Alistair S. ; Harris, Tamara B. ; Hattersley, Andrew T. ; Heath, Andrew C. ; Hengstenberg, Christian ; Hicks, Andrew A. ; Hindorff, Lucia A. ; Hingorani, Aroon D. ; Hofman, Albert ; Hovingh, G. Kees ; Humphries, Steve E. ; Hunt, Steven C. ; Hypponen, Elina ; Jacobs, Kevin B. ; Jarvelin, Marjo-Riitta ; Jousilahti, Pekka ; Jula, Antti M. ; Kaprio, Jaakko ; Kastelein, John J. P. ; Kayser, Manfred ; Kee, Frank ; Keinanen-Kiukaanniemi, Sirkka M. ; Kiemeney, Lambertus A. ; Kooner, Jaspal S. ; Kooperberg, Charles ; Koskinen, Seppo ; Kovacs, Peter ; Kraja, Aldi T. ; Kumari, Meena ; Kuusisto, Johanna ; Lakka, Timo A. ; Langenberg, Claudia ; Le Marchand, Loic ; Lehtimaki, Terho ; Lupoli, Sara ; Madden, Pamela A. F. ; Mannisto, Satu ; Manunta, Paolo ; Marette, Andre ; Matise, Tara C. ; Mcknight, Barbara ; Meitinger, Thomas ; Moll, Frans L. ; Montgomery, Grant W. ; Morris, Andrew D. ; Morris, Andrew P. ; Murray, Jeffrey C. ; Nelis, Mari ; Ohlsson, Claes ; Oldehinkel, Albertine J. ; Ong, Ken K. ; Ouwehand, Willem H. ; Pasterkamp, Gerard ; Peters, Annette ; Pramstaller, Peter P. ; Price, Jackie F. ; Qi, Lu ; Raitakari, Olli T. ; Rankinen, Tuomo ; Rao, D. C. ; Rice, Treva K. ; Ritchie, Marylyn ; Rudan, Igor ; Salomaa, Veikko ; Samani, Nilesh J. ; Saramies, Jouko ; Sarzynski, Mark A. ; Schwarz, Peter E. H. ; Sebert, Sylvain ; Sever, Peter ; Shuldiner, Alan R. ; Sinisalo, Juha ; Steinthorsdottir, Valgerdur ; Stolk, Ronald P. ; Tardif, Jean-Claude ; Toenjes, Anke ; Tremblay, Angelo ; Tremoli, Elena ; Virtamo, Jarmo ; Vohl, Marie-Claude ; Amouyel, Philippe ; Asselbergs, Folkert W. ; Assimes, Themistocles L. ; Bochud, Murielle ; Boehm, Bernhard O. ; Boerwinkle, Eric ; Bottinger, Erwin P. ; Bouchard, Claude ; Cauchi, Stephane ; Chambers, John C. ; Chanock, Stephen J. ; Cooper, Richard S. ; De Bakker, Paul I. W. ; Dedoussis, George ; Ferrucci, Luigi ; Franks, Paul W. ; Froguel, Philippe ; Groop, Leif C. ; Haiman, Christopher A. ; Hamsten, Anders ; Hayes, M. Geoffrey ; Hui, Jennie ; Hunter, David J. ; Hveem, Kristian ; Jukema, J. Wouter ; Kaplan, Robert C. ; Kivimaki, Mika ; Kuh, Diana ; Laakso, Markku ; Liu, Yongmei ; Martin, Nicholas G. ; Maerz, Winfried ; Melbye, Mads ; Moebus, Susanne ; Munroe, Patricia B. ; Njolstad, Inger ; Oostra, Ben A. ; Palmer, Colin N. A. ; Pedersen, Nancy L. ; Perola, Markus ; Perusse, Louis ; Peters, Ulrike ; Powell, Joseph E. ; Power, Chris ; Quertermous, Thomas ; Rauramaa, Rainer ; Reinmaa, Eva ; Ridker, Paul M. ; Rivadeneira, Fernando ; Rotter, Jerome I. ; Saaristo, Timo E. ; Saleheen, Danish ; Schlessinger, David ; Slagboom, P. Eline ; Snieder, Harold ; Spector, Tim D. ; Strauch, Konstantin ; Stumvoll, Michael ; Tuomilehto, Jaakko ; Uusitupa, Matti ; Van Der Harst, Pim ; Voelzke, Henry ; Walker, Mark ; Wareham, Nicholas J. ; Watkins, Hugh ; Wichmann, H-Erich ; Wilson, James F. ; Zanen, Pieter ; Deloukas, Panos ; Heid, Iris M. ; Lindgren, Cecilia M. ; Mohlke, Karen L. ; Speliotes, Elizabeth K. ; Thorsteinsdottir, Unnur ; Barroso, Ines ; Fox, Caroline S. ; North, Kari E. ; Strachan, David P. ; Beckmann, Jacques S. ; Berndt, Sonja I. ; Boehnke, Michael ; Borecki, Ingrid B. ; Mccarthy, Mark I. ; Metspalu, Andres ; Stefansson, Kari ; Uitterlinden, Andre G. ; Van Duijn, Cornelia M. ; Franke, Lude ; Willer, Cristen J. ; Price, Alkes L. ; Lettre, Guillaume ; Loos, Ruth J. F. ; Weedon, Michael N. ; Ingelsson, Erik ; O'Connell, Jeffrey R. ; Abecasis, Goncalo R. ; Chasman, Daniel I. ; Goddard, Michael E. ; Visscher, Peter M. ; Hirschhorn, Joel N. ; Frayling, Timothy M. ; Elect Med Records & Genom eMERGE C; MIGen Consortium; PAGE Consortium; LifeLines Cohort Study
Published in
Nature Genetics
Pagination
14
Volume
46
Issue
11
Pages
1173-1186
Date
2014
Publisher
New York, Nature Publishing Group
ISSN
1061-4036
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View record in Web of Science
Laboratories
GHI
Record Appears in
Scientific production and competences > SV - School of Life Sciences > GHI - Global Health Institute > UNATTRIBUTED-GHI - GHI - Unattributed publications
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2014-12-30