Highly water soluble trithiolato-bridged dinuclear arene ruthenium complexes
Water soluble arene-functionalised trithiolato-bridged ruthenium complexes of general formula [(eta(6)-C6H5OCH2CH2OH)(2)Ru-2(mu-SR)(3)](+), where R = C6H5 (1), C6H4-p-OMe (2), C6H4-p-OMe (3), C6H4-p-Pr-i (4), C6H4-p-Bu-t (5), CH2C6H5 (6), CH2CH2C6H5 (7) and CH2C6H4-p-Bu-t (8), were prepared from the reaction of [(eta(6)-C6H5OCH2CH2OH)(2)Ru-2(mu-Cl)(2)Cl-2] with the corresponding thiol, RSH. Complexes  Cl-Cl were isolated in good yields as their chloride salts and they were fully characterised using spectroscopic and analytical techniques and the structures of Cl, Cl and Cl were determined in the solid-state by single-crystal X-ray diffraction. The antiproliferative activity of Cl-Cl was evaluated against human ovarian cancer (A2780, A2780cisR) and non-cancerous (HEK293) cells with Cl and Cl being more active than cisplatin on the cancer cells and also more selective. (C) 2014 Elsevier B.V. All rights reserved.