000204077 001__ 204077
000204077 005__ 20181203023718.0
000204077 0247_ $$2doi$$a10.1016/j.ica.2014.07.050
000204077 022__ $$a0020-1693
000204077 02470 $$2ISI$$a000345115900005
000204077 037__ $$aARTICLE
000204077 245__ $$aAntiproliferative activities of trithiolato-bridged dinuclear arene osmium complexes
000204077 260__ $$bElsevier Science Sa$$c2014$$aLausanne
000204077 269__ $$a2014
000204077 300__ $$a5
000204077 336__ $$aJournal Articles
000204077 520__ $$aTrithiolato-bridged arene osmium complexes of the general formula [(p-cymene)(2)Os-2(mu-SR)(3)](+) (R = C6H5, [1](+); C6H4-p-Me, [2](+); C6H4-p-OMe, [3](+); C6H4-p-Pr-i, [4](+); C6H4-p-But, [5](+); CH2C6H5, [6](+); CH2CH2C6H5, [7](+); CH2C6H4-p-Bu-t, [8](+)) were synthesized in ethanol by reacting the p-cymene osmium dimer [(p-cymene)(2)Os-2(mu-Cl)(2)Cl-2] with the corresponding thiol (RSH). The complexes were isolated as their chloride salts, and fully characterized by spectroscopic methods. The single-crystal X-ray structure analysis of the salt [6]Cl is also presented. These osmium complexes were found to be highly cytotoxic towards several cancerous cell lines (A2780, A549, B16F10, HeLa) with IC50 values comparable or even better to those found for doxorubicin. (C) 2014 Elsevier B.V. All rights reserved.
000204077 6531_ $$aAntiproliferative activity
000204077 6531_ $$aArene osmium
000204077 6531_ $$aBioorganometallic
000204077 6531_ $$aDinuclear complexes
000204077 6531_ $$aThiolato-bridging ligands
000204077 700__ $$uUniv Neuchatel, Inst Chem, CH-2000 Neuchatel, Switzerland$$aGupta, Gajendra
000204077 700__ $$uCSIR, Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India$$aNagesh, Narayana
000204077 700__ $$0245493$$g214821$$aMurray, Benjamin S.
000204077 700__ $$0240015$$g149418$$aDyson, Paul J.
000204077 700__ $$aTherrien, Bruno$$uUniv Neuchatel, Inst Chem, CH-2000 Neuchatel, Switzerland
000204077 773__ $$j423$$tInorganica Chimica Acta$$q31-35
000204077 909C0 $$xU9$$0252010$$pLCOM
000204077 909CO $$pSB$$particle$$ooai:infoscience.tind.io:204077
000204077 917Z8 $$x135992
000204077 937__ $$aEPFL-ARTICLE-204077
000204077 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000204077 980__ $$aARTICLE