Transition Metal-Free Intermolecular alpha-C-H Amination of Ethers at Room Temperature

We describe a new method for the intermolecular amination of the alpha-C-H bonds of ethers. A hypervalent iodine reagent was used as oxidant to enable the amination of cyclic and acyclic alkyl ethers with a wide range of amides, imides, and amines. The amination occurred at room temperature and without a transition metal catalyst. The method could be used to synthesize the anti-cancer prodrug Tegafur and its analogues.


Published in:
Advanced Synthesis & Catalysis, 356, 16, 3325-3330
Year:
2014
Publisher:
Weinheim, Wiley-Blackwell
ISSN:
1615-4150
Keywords:
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 Record created 2014-12-30, last modified 2018-01-28

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