Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish
Macikova, Petra; Groh, Ksenia J.; Ammann, Adrian A.; Schirmer, Kristin; Suter, Marc J. -F.
2014

Abstract

This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 mu g/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from

Details

Title Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish
Author(s) Macikova, Petra ; Groh, Ksenia J. ; Ammann, Adrian A. ; Schirmer, Kristin ; Suter, Marc J. -F.
Published in Environmental Science & Technology
Pagination 10
Volume 48
Issue 21
Pages 12902-12911
Date 2014
Publisher Washington, Amer Chemical Soc
ISSN 0013-936X
DOI https://doi.org/10.1021/es502711c
Other identifier(s) View record in Web of Science
Laboratories TOX
Record Appears in Scientific production and competences > ENAC - School of Architecture, Civil and Environmental Engineering > IIE - Environmental Engineering Institute > TOX - Laboratory of Environmental Toxicology
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2014-12-30

Actions