000203229 001__ 203229
000203229 005__ 20181203023650.0
000203229 0247_ $$2doi$$a10.1016/j.cell.2014.08.011
000203229 022__ $$a0092-8674
000203229 02470 $$2ISI$$a000343094200011
000203229 037__ $$aARTICLE
000203229 245__ $$aA Dual Program for Translation Regulation in Cellular Proliferation and Differentiation
000203229 269__ $$a2014
000203229 260__ $$bCell Press$$c2014$$aCambridge
000203229 300__ $$a12
000203229 336__ $$aJournal Articles
000203229 520__ $$aA dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the opposite signature. Correspondingly, we found that genes serving cell-autonomous functions and genes involved in multicellularity obey distinct codon usage. Proliferation-induced and differentiation-induced tRNAs often carry anticodons that correspond to the codons enriched among the cell-autonomous and the multicellularity genes, respectively. Because mRNAs of cell-autonomous genes are induced in proliferation and cancer in particular, the concomitant induction of their codon-enriched tRNAs suggests coordination between transcription and translation. Histone modifications indeed change similarly in the vicinity of cell-autonomous genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the existence of transcriptional programs coordinating tRNA supply and demand. Hence, we describe the existence of two distinct translation programs that operate during proliferation and differentiation.
000203229 700__ $$uWeizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel$$aGingold, Hila
000203229 700__ $$uUniv Copenhagen, Biotech Res & Innovat Ctr, DK-2200 Copenhagen, Denmark$$aTehler, Disa
000203229 700__ $$uUniv Copenhagen, Biotech Res & Innovat Ctr, DK-2200 Copenhagen, Denmark$$aChristoffersen, Nanna R.
000203229 700__ $$uAarhus Univ Hosp, Dept Mol Med, DK-8000 Aarhus, Denmark$$aNielsen, Morten M.
000203229 700__ $$uUniv Copenhagen, Rigshosp, Dept Hematol, DK-2100 Copenhagen, Denmark$$aAsmar, Fazila
000203229 700__ $$uUniv Copenhagen, Biotech Res & Innovat Ctr, DK-2200 Copenhagen, Denmark$$aKooistra, Susanne M.
000203229 700__ $$uUniv Copenhagen, Biotech Res & Innovat Ctr, DK-2200 Copenhagen, Denmark$$aChristophersen, Nicolaj S.
000203229 700__ $$aChristensen, Lise Lotte
000203229 700__ $$uAarhus Univ Hosp, Dept Urol, DK-8000 Aarhus, Denmark$$aBorre, Michael
000203229 700__ $$uAarhus Univ Hosp, Dept Mol Med, DK-8000 Aarhus, Denmark$$aSorensen, Karina D.
000203229 700__ $$uAarhus Univ Hosp, Dept Mol Med, DK-8000 Aarhus, Denmark$$aAndersen, Lars D.
000203229 700__ $$uAarhus Univ Hosp, Dept Mol Med, DK-8000 Aarhus, Denmark$$aAndersen, Claus L.
000203229 700__ $$uVrije Univ Amsterdam, Med Ctr, Canc Ctr Amsterdam, Dept Pediat Oncol, NL-1007 MB Amsterdam, Netherlands$$aHulleman, Esther
000203229 700__ $$uVrije Univ Amsterdam, Med Ctr, Canc Ctr Amsterdam, Dept Neurosurg,Neurooncol Res Grp, NL-1007 MB Amsterdam, Netherlands$$aWurdinger, Tom
000203229 700__ $$uUniv Copenhagen, Rigshosp, Dept Pathol, DK-2100 Copenhagen, Denmark$$aRalfkiaer, Elisabeth
000203229 700__ $$uUniv Copenhagen, Biotech Res & Innovat Ctr, DK-2200 Copenhagen, Denmark$$aHelin, Kristian
000203229 700__ $$uUniv Copenhagen, Rigshosp, Dept Hematol, DK-2100 Copenhagen, Denmark$$aGronbaek, Kirsten
000203229 700__ $$uAarhus Univ Hosp, Dept Mol Med, DK-8000 Aarhus, Denmark$$aOmtoft, Torben
000203229 700__ $$aWaszak, Sebastian M.
000203229 700__ $$uWeizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel$$aDahan, Orna
000203229 700__ $$uAarhus Univ Hosp, Dept Mol Med, DK-8000 Aarhus, Denmark$$aPedersen, Jakob Skou
000203229 700__ $$uUniv Copenhagen, Biotech Res & Innovat Ctr, DK-2200 Copenhagen, Denmark$$aLund, Anders H.
000203229 700__ $$uWeizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel$$aPilpel, Yitzhak
000203229 773__ $$j158$$tCell$$k6$$q1281-1292
000203229 909C0 $$0252444$$pIBI
000203229 909CO $$particle$$ooai:infoscience.tind.io:203229$$pSV$$pSTI
000203229 937__ $$aEPFL-ARTICLE-203229
000203229 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000203229 980__ $$aARTICLE