The combined effect of dislocation source strength tau(s), dislocation obstacle strength tau(obs), and obstacle spacing L(obs) on the yield stress of single crystal metals is investigated analytically and numerically. A continuum theory of dislocation pileups emanating from a finite-strength source and impinging on asymmetric obstacles gives a closed-form expression for the yield stress. A 2d discrete dislocation model for a single-source/obstacle problem agrees well with the analytic model over a wide range of material parameters. Discrete dislocation simulations for a full tensile bar with statistically distributed sources and obstacles show that the distribution of obstacles plays a significant role in controlling the yield stress. Over a wide range of parameters, the simulations agree well with the analytic model using an effective obstacle spacing L(obs) chosen to capture the strength-controlling statistically weaker pileup configurations. The analytic model can thus be used to guide the choice of source and obstacle parameters to obtain a desired yield stress. The model also shows how different combinations of internal source and obstacle parameters can generate the same macroscopic yield stress, and points to several internal length scales that could relate to size-dependent plasticity phenomena. (C) 2010 Elsevier Ltd. All rights reserved.