000202771 001__ 202771
000202771 005__ 20190522142440.0
000202771 0247_ $$2doi$$a10.1093/infdis/jiu214
000202771 022__ $$a1537-6613
000202771 02470 $$2ISI$$a000344609100007
000202771 037__ $$aARTICLE
000202771 245__ $$aHLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A
000202771 260__ $$c2014$$bOxford University Press$$aCary
000202771 269__ $$a2014
000202771 300__ $$a5
000202771 336__ $$aJournal Articles
000202771 500__ $$aNational Licences
000202771 520__ $$aA recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-Δ32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using controls from the general population. Our data indicate that HLA class I alleles, presence or absence of KIR genes, and functionally relevant combinations of the HLA/KIR genotypes are not involved in resistance to parenterally transmitted HIV-1 infection.
000202771 6531_ $$aHESN
000202771 6531_ $$ahemophilia
000202771 6531_ $$aHIV-1
000202771 6531_ $$aHLA
000202771 6531_ $$aKIR
000202771 700__ $$aVince, Nicolas
000202771 700__ $$aBashirova, Arman A
000202771 700__ $$aLied, Alexandra
000202771 700__ $$aGao, Xiaojiang
000202771 700__ $$aDorrell, Lucy
000202771 700__ $$0246150$$g221280$$aMcLaren, Paul J
000202771 700__ $$g213497$$aFellay, Jacques$$0245371
000202771 700__ $$aCarrington, Mary
000202771 773__ $$j210$$tThe Journal of infectious diseases$$k7$$q1047-51
000202771 8564_ $$uhttps://infoscience.epfl.ch/record/202771/files/jiu214.pdf$$zPUBLISHER'S VERSION$$s115176
000202771 909C0 $$xU12477$$0252395$$pGR-FE
000202771 909CO $$pSV$$particle$$ooai:infoscience.tind.io:202771
000202771 917Z8 $$x213497
000202771 937__ $$aEPFL-ARTICLE-202771
000202771 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000202771 980__ $$aARTICLE