000202730 001__ 202730
000202730 005__ 20190317000036.0
000202730 037__ $$aPOST_TALK
000202730 245__ $$aAnalysis of the dynamics and competition for resources in the system of protein translation using stochastic simulations
000202730 269__ $$a2013
000202730 260__ $$c2013
000202730 336__ $$aPosters
000202730 500__ $$aAbstract published under the following name: Computational analysis of the interplay between tRNA competitive behavior and decoding type on the modulation of translation elongation rate
000202730 520__ $$aProtein synthesis plays an important role in biological systems since its products, proteins and enzymes, constitute most of the molecular machinery required for cell regulation, growth and function in the tissue. Understanding the mechanisms of decoding and its rate limiting steps is crucial for the development of target drugs. A deterministic model based on kinetic description of the ribosomal pathway showed that competitive tRNA behavior was a determinant of codon elongation rates, whereas a recent work proposes Watson-Crick and non-Watson-Crick types of decoding as the main determinant. We use a stochastic algorithm to model the translation process using a mechanistic model for ribosomal kinetics that accounts for both competitive tRNA behavior and Watson-Crick and non-Watson-Crick types of decoding. With this framework we simulate an E. coli translating gene pool and analyze the effects of codon usage in the exploitation of ribosomes and tRNA resources.
000202730 700__ $$0246111$$g183193$$aPinto Vieira, Joana
000202730 700__ $$0244253$$g160001$$aRacle, Julien
000202730 700__ $$0240657$$g174688$$aHatzimanikatis, Vassily
000202730 7112_ $$dJuly 13-17, 2013$$cLisbon. Portugal$$a9th European Biophysics Congress
000202730 8564_ $$uhttp://link.springer.com/article/10.1007%2Fs00249-013-0917-x$$zURL
000202730 8564_ $$uhttps://infoscience.epfl.ch/record/202730/files/EBSA2013Lisbon.pdf$$zn/a$$s2703739$$yn/a
000202730 909C0 $$xU11422$$0252131$$pLCSB
000202730 909CO $$ooai:infoscience.tind.io:202730$$qGLOBAL_SET$$pSB$$pposter
000202730 917Z8 $$x183193
000202730 917Z8 $$x183193
000202730 917Z8 $$x183193
000202730 937__ $$aEPFL-POSTER-202730
000202730 973__ $$aOTHER
000202730 980__ $$aPOSTER