000202552 001__ 202552
000202552 005__ 20190317000032.0
000202552 0247_ $$2doi$$a10.1371/journal.pone.0100096
000202552 022__ $$a1932-6203
000202552 02470 $$2ISI$$a000340721500044
000202552 037__ $$aARTICLE
000202552 245__ $$aA Dimerized HMX1 Inhibits EPHA6/epha4b in Mouse and Zebrafish Retinas
000202552 269__ $$a2014
000202552 260__ $$aSan Francisco$$bPublic Library of Science$$c2014
000202552 300__ $$a11
000202552 336__ $$aJournal Articles
000202552 520__ $$aHMX1 is a homeobox-containing transcription factor implicated in eye development and responsible for the oculo-auricular syndrome of Schorderet-Munier-Franceschetti. HMX1 is composed of two exons with three conserved domains in exon 2, a homeobox and two domains called SD1 and SD2. The function of the latter two domains remains unknown. During retinal development, HMX1 is expressed in a polarized manner and thus seems to play a role in the establishment of retinal polarity although its exact role and mode of action in eye development are unknown. Here, we demonstrated that HMX1 dimerized and that the SD1 and homeodomains are required for this function. In addition, we showed that proper nuclear localization requires the presence of the homeodomain. We also identified that EPHA6, a gene implicated in retinal axon guidance, is one of its targets in eye development and showed that a dimerized HMX1 is needed to inhibit EPHA6 expression.
000202552 700__ $$aMarcelli, Fabienne$$uIRO Inst Res Ophthalmol, Sion, Switzerland
000202552 700__ $$aBoisset, Gaelle$$uIRO Inst Res Ophthalmol, Sion, Switzerland
000202552 700__ $$aSchorderet, Daniel F.$$uIRO Inst Res Ophthalmol, Sion, Switzerland
000202552 773__ $$j9$$k6$$qe100096$$tPlos One
000202552 8564_ $$s2369083$$uhttps://infoscience.epfl.ch/record/202552/files/journal.pone.0100096.pdf$$yPublisher's version$$zPublisher's version
000202552 909C0 $$0252372$$pSV$$xU10445
000202552 909CO $$ooai:infoscience.tind.io:202552$$pSV$$particle$$qGLOBAL_SET
000202552 917Z8 $$x182396
000202552 937__ $$aEPFL-ARTICLE-202552
000202552 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000202552 980__ $$aARTICLE