000202545 001__ 202545
000202545 005__ 20181203023635.0
000202545 0247_ $$2doi$$a10.1038/ncomms5482
000202545 022__ $$a2041-1723
000202545 02470 $$2ISI$$a000340623400027
000202545 037__ $$aARTICLE
000202545 245__ $$aLipid tail protrusions mediate the insertion of nanoparticles into model cell membranes
000202545 260__ $$bNature Publishing Group$$c2014$$aLondon
000202545 269__ $$a2014
000202545 300__ $$a11
000202545 336__ $$aJournal Articles
000202545 520__ $$aRecent work has demonstrated that charged gold nanoparticles (AuNPs) protected by an amphiphilic organic monolayer can spontaneously insert into the core of lipid bilayers to minimize the exposure of hydrophobic surface area to water. However, the kinetic pathway to reach the thermodynamically stable transmembrane configuration is unknown. Here, we use unbiased atomistic simulations to show the pathway by which AuNPs spontaneously insert into bilayers and confirm the results experimentally on supported lipid bilayers. The critical step during this process is hydrophobic-hydrophobic contact between the core of the bilayer and the monolayer of the AuNP that requires the stochastic protrusion of an aliphatic lipid tail into solution. This last phenomenon is enhanced in the presence of high bilayer curvature and closely resembles the putative pre-stalk transition state for vesicle fusion. To the best of our knowledge, this work provides the first demonstration of vesicle fusion-like behaviour in an amphiphilic nanoparticle system.
000202545 700__ $$uMIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA$$aVan Lehn, Reid C.
000202545 700__ $$0245061$$g204528$$uEcole Polytech Fed Lausanne, Inst Mat, CH-1015 Lausanne, Switzerland$$aRicci, Maria
000202545 700__ $$uEcole Polytech Fed Lausanne, Inst Mat, CH-1015 Lausanne, Switzerland$$aSilva, Paulo H. J.
000202545 700__ $$uIRCCS Fdn Inst Neurol Carlo Besta, I-20139 Milan, Italy$$aAndreozzi, Patrizia
000202545 700__ $$uEcole Polytech Fed Lausanne, Inst Mat, CH-1015 Lausanne, Switzerland$$aReguera, Javier
000202545 700__ $$0244843$$g202038$$aVoitchovsky, Kislon
000202545 700__ $$uEcole Polytech Fed Lausanne, Inst Mat, CH-1015 Lausanne, Switzerland$$aStellacci, Francesco$$g196998$$0244724
000202545 700__ $$aAlexander-Katz, Alfredo
000202545 773__ $$j5$$tNature Communications$$q4482
000202545 909C0 $$xU12173$$0252323$$pSUNMIL
000202545 909CO $$pSTI$$particle$$ooai:infoscience.tind.io:202545
000202545 917Z8 $$x196998
000202545 917Z8 $$x148230
000202545 937__ $$aEPFL-ARTICLE-202545
000202545 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000202545 980__ $$aARTICLE