000202350 001__ 202350
000202350 005__ 20181203023631.0
000202350 0247_ $$2doi$$a10.1101/gad.246140.114
000202350 022__ $$a0890-9369
000202350 02470 $$2ISI$$a000341674700004
000202350 037__ $$aARTICLE
000202350 245__ $$aPax6-dependent, but beta-catenin-independent, function of Bcl9 proteins in mouse lens development
000202350 260__ $$bCold Spring Harbor Laboratory Press$$c2014$$aCold Spring Harbor
000202350 269__ $$a2014
000202350 300__ $$a6
000202350 336__ $$aJournal Articles
000202350 520__ $$aBcl9 and Bcl9l (Bcl9/9l) encode Wnt signaling components that mediate the interaction between beta-catenin and Pygopus (Pygo) via two evolutionarily conserved domains, HD1 and HD2, respectively. We generated mouse strains lacking these domains to probe the beta-catenin-dependent and beta-catenin-independent roles of Bcl9/9l and Pygo during mouse development. While lens development is critically dependent on the presence of the HD1 domain, it is not affected by the lack of the HD2 domain, indicating that Bcl9/9l act in this context in a beta-catenin-independent manner. Furthermore, we uncover a new regulatory circuit in which Pax6, the master regulator of eye development, directly activates Bcl9/9l transcription.
000202350 6531_ $$aWnt
000202350 6531_ $$amouse
000202350 6531_ $$aBcl9
000202350 6531_ $$aPygopus
000202350 6531_ $$alens induction
000202350 6531_ $$aPax6
000202350 700__ $$aCantù, Claudio
000202350 700__ $$aZimmerli, Dario
000202350 700__ $$aHausmann, George
000202350 700__ $$aValenta, Thomas
000202350 700__ $$aMoor, Andreas
000202350 700__ $$0240585$$g168669$$aAguet, Michel
000202350 700__ $$aBasler, Konrad
000202350 773__ $$j28$$tGenes & Development$$k17$$q1879-1884
000202350 909C0 $$xU11156$$0252150$$pUPAGU
000202350 909CO $$pSV$$particle$$ooai:infoscience.tind.io:202350
000202350 917Z8 $$x168669
000202350 937__ $$aEPFL-ARTICLE-202350
000202350 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000202350 980__ $$aARTICLE