000202258 001__ 202258
000202258 005__ 20181203023628.0
000202258 022__ $$a0022-3166
000202258 02470 $$2ISI$$a000342329900005
000202258 0247_ $$2doi$$a10.3945/jn.114.193565
000202258 037__ $$aARTICLE
000202258 245__ $$aA dose-response strategy reveals differences between normal-weight and obese men in their metabolic and inflammatory responses to a high-fat meal
000202258 269__ $$a2014
000202258 260__ $$aBethesda$$bAmer Soc Nutrition-Asn$$c2014
000202258 300__ $$a7
000202258 336__ $$aJournal Articles
000202258 520__ $$aA dose-response strategy may not only allow investigation of the impact of foods and nutrients on human health but may also reveal differences in the response of individuals to food ingestion based on their metabolic health status. In a randomized crossover study, we challenged 19 normal-weight (BMI: 20-25 kg/m(2)) and 18 obese (BMI: >30 kg/m(2)) men with 500, 1000, and 1500 kcal of a high-fat (HF) meal (60.5% energy from fat). Blood was taken at baseline and up to 6 h postprandially and analyzed for a range of metabolic, inflammatory, and hormonal variables, including plasma glucose, lipids, and C-reactive protein and serum insulin, glucagon-like peptide-1, interleukin-6 (IL-6), and endotoxin. Insulin was the only variable that could differentiate the postprandial response of normal-weight and obese participants at each of the 3 caloric doses. A significant response of the inflammatory marker IL-6 was only observed in the obese group after ingestion of the HF meal containing 1500 kcal [net incremental AUC (iAUC) = 22.9 +/- 6.8 pg/mL x 6 h, P = 0.002]. Furthermore, the net iAUC for triglycerides significantly increased from the 1000 to the 1500 kcal meal in the obese group (5.0 +/- 0.5 mmol/L X 6 h vs. 6.0 +/- 0.5 mmol/L X 6 h; P=0.015) but not in the normal-weight group (4.3 +/- 0.5 mmol/L X 6 h vs. 4.8 +/- 0.5 mmol/L x 6 h; P=0.31). We propose that caloric dose-response studies may contribute to a better understanding of the metabolic impact of food on the human organism. This study was registered at clinicaltrials.gov as NCT01446068.
000202258 700__ $$aSchwander, Flurina$$uAgroscope, Inst Food Sci, Fed Off Agr, Bern, Switzerland
000202258 700__ $$aKopf-Bolanz, Katrin A.$$uUniv Hosp Bern, Div Endocrinol Diabet & Clin Nutr, CH-3010 Bern, Switzerland
000202258 700__ $$aBuri, Caroline$$uAgroscope, Inst Food Sci, Fed Off Agr, Bern, Switzerland
000202258 700__ $$aPortmann, Reto$$uAgroscope, Inst Food Sci, Fed Off Agr, Bern, Switzerland
000202258 700__ $$aEgger, Lotti$$uAgroscope, Inst Food Sci, Fed Off Agr, Bern, Switzerland
000202258 700__ $$aChollet, Magali
000202258 700__ $$aMcternan, Philip G.$$uUniv Warwick, Div Metab & Vasc Hlth, Coventry CV4 7AL, W Midlands, England
000202258 700__ $$aPiya, Milan K.$$uEcole Polytech Fed Lausanne, Lab Microsyst 2, Lausanne, Switzerland
000202258 700__ $$0242801$$aGijs, Martin A. M.$$g113762
000202258 700__ $$aVionnet, Nathalie
000202258 700__ $$aPralong, Francois$$uUniv Hosp Bern, Div Endocrinol Diabet & Clin Nutr, CH-3010 Bern, Switzerland
000202258 700__ $$aLaederach, Kurt$$uAgroscope, Inst Food Sci, Fed Off Agr, Bern, Switzerland
000202258 700__ $$aVergeres, Guy
000202258 773__ $$j144$$k10$$q1517-1523$$tJournal Of Nutrition
000202258 909C0 $$0252094$$pLMIS2$$xU10322
000202258 909CO $$ooai:infoscience.tind.io:202258$$pSTI$$particle
000202258 917Z8 $$x113762
000202258 937__ $$aEPFL-ARTICLE-202258
000202258 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000202258 980__ $$aARTICLE