000202167 001__ 202167
000202167 005__ 20190317000028.0
000202167 0247_ $$2doi$$a10.1016/j.cell.2011.09.035
000202167 022__ $$a1097-4172
000202167 037__ $$aARTICLE
000202167 245__ $$aThe Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma
000202167 269__ $$a2011
000202167 260__ $$c2011
000202167 336__ $$aJournal Articles
000202167 520__ $$aInsights into cancer genetics can lead to therapeutic opportunities. By cross-referencing chromosomal changes with an unbiased genetic screen we identify the ephrin receptor A7 (EPHA7) as a tumor suppressor in follicular lymphoma (FL). EPHA7 is a target of 6q deletions and inactivated in 72% of FLs. Knockdown of EPHA7 drives lymphoma development in a murine FL model. In analogy to its physiological function in brain development, a soluble splice variant of EPHA7 (EPHA7(TR)) interferes with another Eph-receptor and blocks oncogenic signals in lymphoma cells. Consistent with this drug-like activity, administration of the purified EPHA7(TR) protein produces antitumor effects against xenografted human lymphomas. Further, by fusing EPHA7(TR) to the anti-CD20 antibody (rituximab) we can directly target this tumor suppressor to lymphomas in vivo. Our study attests to the power of combining descriptive tumor genomics with functional screens and reveals EPHA7(TR) as tumor suppressor with immediate therapeutic potential.
000202167 6531_ $$aGenes
000202167 6531_ $$aTumor Suppressor
000202167 700__ $$0248688$$g253104$$aOricchio, Elisa
000202167 700__ $$aNanjangud, Gouri
000202167 700__ $$aWolfe, Andrew L.
000202167 700__ $$aSchatz, Jonathan H.
000202167 700__ $$aMavrakis, Konstantinos J.
000202167 700__ $$aJiang, Man
000202167 700__ $$aLiu, Xiaoping
000202167 700__ $$aBruno, Joanne
000202167 700__ $$aHeguy, Adriana
000202167 700__ $$aOlshen, Adam B.
000202167 700__ $$aSocci, Nicholas D.
000202167 700__ $$aTeruya-Feldstein, Julie
000202167 700__ $$aWeis-Garcia, Frances
000202167 700__ $$aTam, Wayne
000202167 700__ $$aShaknovich, Rita
000202167 700__ $$aMelnick, Ari
000202167 700__ $$aHimanen, Juha P.
000202167 700__ $$aChaganti, R. S. K.
000202167 700__ $$aWendel, Hans-Guido
000202167 773__ $$j147$$tCell$$k3$$q554-64
000202167 8564_ $$uhttps://infoscience.epfl.ch/record/202167/files/nihms328987.pdf$$zPostprint$$s4842123$$yPostprint
000202167 909C0 $$xU12997$$0252514$$pUPORICCHIO
000202167 909CO $$ooai:infoscience.tind.io:202167$$qGLOBAL_SET$$pSV$$particle
000202167 917Z8 $$x182396
000202167 937__ $$aEPFL-ARTICLE-202167
000202167 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000202167 980__ $$aARTICLE