000201941 001__ 201941
000201941 005__ 20190317000013.0
000201941 0247_ $$2doi$$a10.2533/chimia.2014.629
000201941 02470 $$2ISI$$a000342477000009
000201941 037__ $$aARTICLE
000201941 245__ $$aPredicting the genes regulated by microRNAs via binding sites in the 3' untranslated and coding regions
000201941 269__ $$a2014
000201941 260__ $$aBern$$bSwiss Chemical Soc$$c2014
000201941 300__ $$a4
000201941 336__ $$aJournal Articles
000201941 520__ $$aMicroRNAs form one of the groups of small noncoding RNA molecules that have completely changed our understanding of gene regulatory networks. Because microRNAs have been discovered only relatively recently, most of their functions remain unknown, providing a challenge to both experiment and theory. I review several computational approaches pursued in our group to answer this challenge. In particular, I show that a few rather simple ideas can go a long way in predicting accurately genes regulated by microRNAs via binding sites both in the coding and 3' untranslated regions (3'UTRs). Finally, I mention briefly several applications, including two collaborations with experimental groups, which have shed new light on the latency and reactivation of herpesviruses, and on the maturation of red blood cells.
000201941 6531_ $$aCONSERVATION
000201941 6531_ $$aMICRORNA
000201941 6531_ $$aMICRORNA TARGET
000201941 6531_ $$aRNA SECONDARY STRUCTURE
000201941 6531_ $$aTARGET PREDICTION ALGORITHM
000201941 700__ $$0240352$$aVanicek, Jiri$$g181577
000201941 773__ $$j68$$k9$$q629-632$$tCHIMIA International Journal for Chemistry
000201941 8564_ $$uhttp://dx.doi.org/10.2533/chimia.2014.629$$zURL
000201941 8564_ $$s218621$$uhttps://infoscience.epfl.ch/record/201941/files/s9.pdf$$yPublisher's version$$zPublisher's version
000201941 909C0 $$0252116$$pLCPT$$xU11812
000201941 909CO $$ooai:infoscience.tind.io:201941$$pSB$$particle$$qGLOBAL_SET
000201941 917Z8 $$x186112
000201941 917Z8 $$x263863
000201941 937__ $$aEPFL-ARTICLE-201941
000201941 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000201941 980__ $$aARTICLE