High Sensitive Detection in Tumor Extracts with SiNW-FET in-Air Biosensors

We have already demonstrated that high quality SiNW-FETs can be used to sense very low concentration range (fM) of pathogenic factors in controlled PBS. In this work we show, for the first time, Silicon Nanowire Field Effect Transistors (SiNW-FET) as biosensors for the detection of antigen in breast tumor extract. We achieved the detection of exogenously added rabbit antigen in a much more complex environment, i.e. a human breast tumor extract. Our preliminary results show specific antigen detection with SiNW-FETs in the range of 5-200 fM. Further and most importantly, the wires sense the antigen in the presence of a 100 000 mass excess of non-specific protein, indicating that the sensor is extremely resistant to noise.


Published in:
Proceedings of the IEEE Sensors 2014, 866-869
Presented at:
IEEE Sensors 2014, Valencia, Spain, November 2-5, 2014
Year:
2014
Publisher:
IEEE
Laboratories:


Note: The status of this file is: EPFL only


 Record created 2014-09-30, last modified 2018-03-17

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