000201837 001__ 201837
000201837 005__ 20190317000010.0
000201837 0247_ $$2doi$$a10.1126/scitranslmed.3008325
000201837 022__ $$a1946-6234
000201837 02470 $$2ISI$$a000343316800010
000201837 037__ $$aARTICLE
000201837 245__ $$aClosed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury
000201837 269__ $$a2014
000201837 260__ $$aWashington$$bAmerican Association for the Advancement of Science$$c2014
000201837 300__ $$a10
000201837 336__ $$aJournal Articles
000201837 520__ $$aNeuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with spinal cord injury. With common neuromodulation devices, electrical stimulation parameters are tuned manually and remain constant during movement. We developed a mechanistic framework to optimize neuromodulation in real time to achieve high-fidelity control of leg kinematics during locomotion in rats. We first uncovered relationships between neuromodulation parameters and recruitment of distinct sensorimotor circuits, resulting in predictive adjustments of leg kinematics. Second, we established a technological platform with embedded control policies that integrated robust movement feedback and feed-forward control loops in real time. These developments allowed us to conceive a neuroprosthetic system that controlled a broad range of foot trajectories during continuous locomotion in paralyzed rats. Animals with complete spinal cord injury performed more than 1000 successive steps without failure, and were able to climb staircases of various heights and lengths with precision and fluidity. Beyond therapeutic potential, these findings provide a conceptual and technical framework to personalize neuromodulation treatments for other neurological disorders.
000201837 700__ $$0246205$$aWenger, Nikolaus$$g220876
000201837 700__ $$0246268$$aMartin Moraud, Eduardo$$g224575
000201837 700__ $$0246240$$aRaspopovic, Stanisa$$g221044
000201837 700__ $$0246242$$aBonizzato, Marco$$g221048
000201837 700__ $$0246243$$aDiGiovanna, Jack$$g221246
000201837 700__ $$0246287$$aMusienko, Pavel$$g226399
000201837 700__ $$aMorari, Manfred
000201837 700__ $$0246201$$aMicera, Silvestro$$g218366
000201837 700__ $$0245952$$aCourtine, Grégoire$$g220184
000201837 773__ $$j6$$k255$$tScience Translational Medicine
000201837 8564_ $$s6857628$$uhttps://infoscience.epfl.ch/record/201837/files/Wegner%20et%20al%202014%20_Supp.pdf$$ySupplementary Information$$zSupplementary Information
000201837 8564_ $$s2205543$$uhttps://infoscience.epfl.ch/record/201837/files/Wenger%20et%20al.%202014.pdf$$yPostprint$$zPostprint
000201837 909C0 $$0252410$$pUPCOURTINE$$xU12556
000201837 909C0 $$0252419$$pTNE$$xU12522
000201837 909C0 $$0252517$$pCNP$$xU12599
000201837 909CO $$ooai:infoscience.tind.io:201837$$pSV$$pSTI$$particle$$qGLOBAL_SET
000201837 917Z8 $$x224825
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000201837 937__ $$aEPFL-ARTICLE-201837
000201837 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000201837 980__ $$aARTICLE