000201780 001__ 201780
000201780 005__ 20190317000009.0
000201780 0247_ $$2doi$$a10.1016/j.biomaterials.2014.09.005
000201780 02470 $$2ISI$$a000343639700025
000201780 037__ $$aARTICLE
000201780 245__ $$aDoes locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo
000201780 269__ $$a2014
000201780 260__ $$bElsevier$$c2014$$aOxford
000201780 300__ $$a12
000201780 336__ $$aJournal Articles
000201780 520__ $$aBisphosphonates are known for their strong inhibitory effect on bone resorption. Their influence on bone formation however is less clear. In this study we investigated the spatio-temporal effect of locally delivered Zoledronate on peri-implant bone formation and resorption in an ovariectomized rat femoral model. A cross-linked hyaluronic acid hydrogel was loaded with the drug and applied bilaterally in predrilled holes before inserting polymer screws. Static and dynamic bone parameters were analyzed based on in vivo microCT scans performed first weekly and then biweekly. The results showed that the locally released Zoledronate boosted bone formation rate up to 100% during the first 17 days after implantation and reduced the bone resorption rate up to 1000% later on. This shift in bone remodeling resulted in an increase in bone volume fraction (BV/TV) by 300% close to the screw and 100% further away. The double effect on bone formation and resorption indicates a great potential of Zoledronate-loaded hydrogel for enhancement of peri-implant bone volume which is directly linked to improved implant fixation.
000201780 6531_ $$aDrug delivery
000201780 6531_ $$aHydrogel
000201780 6531_ $$aBisphosphonate
000201780 6531_ $$aImplant
000201780 6531_ $$aDynamic histomorphometry
000201780 6531_ $$aMicroCT
000201780 700__ $$0244461$$g204848$$aKettenberger, Ulrike
000201780 700__ $$0245905$$g170615$$aSton, Julien
000201780 700__ $$aThein, Eric
000201780 700__ $$aProcter, Philip
000201780 700__ $$aPioletti, Dominique$$g103117$$0240508
000201780 773__ $$j35$$tBiomaterials$$q9995-10006
000201780 8564_ $$uhttps://infoscience.epfl.ch/record/201780/files/Biomaterial%28Ulrike%29.pdf$$zn/a$$s2473599$$yn/a
000201780 909C0 $$xU10299$$0252108$$pLBO
000201780 909CO $$qGLOBAL_SET$$pSTI$$ooai:infoscience.tind.io:201780$$particle
000201780 917Z8 $$x103117
000201780 917Z8 $$x103117
000201780 917Z8 $$x103117
000201780 937__ $$aEPFL-ARTICLE-201780
000201780 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000201780 980__ $$aARTICLE