000201200 001__ 201200
000201200 005__ 20180317093735.0
000201200 0247_ $$2doi$$a10.1002/anie.201404895
000201200 022__ $$a1433-7851
000201200 02470 $$2ISI$$a000339562400038
000201200 037__ $$aARTICLE
000201200 245__ $$aAsymmetric Synthesis of Isoindolones by Chiral Cyclopentadienyl-Rhodium(III)-Catalyzed C-H Functionalizations
000201200 260__ $$aWeinheim$$bWiley-Blackwell$$c2014
000201200 269__ $$a2014
000201200 300__ $$a4
000201200 336__ $$aJournal Articles
000201200 520__ $$aDirected Cp*Rh-III-catalyzed carbon-hydrogen (C-H) bond functionalizations have evolved as a powerful strategy for the construction of heterocycles. Despite their high value, the development of related asymmetric reactions is largely lagging behind due to a limited availability of robust and tunable chiral cyclopentadienyl ligands. Rhodium complexes comprising a chiral Cp ligand with an atropchiral biaryl backbone enables an asymmetric synthesis of isoindolones from arylhydroxamates and weakly alkyl donor/acceptor diazo derivatives as one-carbon component under mild conditions. The complex guides the substrates with a high double facial selectivity yielding the chiral isoindolones in good yields and excellent enantioselectivities.
000201200 6531_ $$aasymmetric catalysis
000201200 6531_ $$aC-H activation
000201200 6531_ $$acyclopentadienyl ligand
000201200 6531_ $$adiazo ester
000201200 6531_ $$arhodium
000201200 700__ $$0245582$$aYe, Baihua$$g162670
000201200 700__ $$0244709$$aCramer, Nicolai$$g206338
000201200 773__ $$j53$$k30$$q7896-7899$$tAngewandte Chemie-International Edition
000201200 909CO $$ooai:infoscience.tind.io:201200$$particle$$pSB
000201200 909C0 $$0252404$$pLCSA$$xU12340
000201200 917Z8 $$x206338
000201200 937__ $$aEPFL-ARTICLE-201200
000201200 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000201200 980__ $$aARTICLE