000201194 001__ 201194
000201194 005__ 20190508073945.0
000201194 022__ $$a0276-7333
000201194 02470 $$2ISI$$a000339647100007
000201194 0247_ $$a10.1021/om500317b$$2doi
000201194 037__ $$aARTICLE
000201194 245__ $$aRuthenium(II)-Arene RAPTA Type Complexes Containing Curcunnin and Bisdemethoxycurcumin Display Potent and Selective Anticancer Activity
000201194 269__ $$a2014
000201194 260__ $$c2014
000201194 300__ $$a7
000201194 336__ $$aJournal Articles
000201194 520__ $$aA series of novel ruthenium(II) arene RAPTA type derivatives (arene = cymene, hexamethylbenzene) containing curcumin-based ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and PTA (1,3,5-triaza-7-phosphaadamantane) have been synthesized and fully characterized. The solid-state structures of [Ru(cym)(curc)-(PTA)][SO3CF3], [Ru(hmb)(curc)(PTA)] [SO3CF3], and [Ru(hmb)(bdcurc)(PTA)]-[SO3CF3] have been determined by single-crystal X-ray diffraction. The antitumor activity of the complexes has been evaluated in vitro against human ovarian carcinoma cells (A2780 and A2780cisR), as well as against nontumorous human embryonic kidney (HEK293) cells. The correlation of the cytotoxicity upon switching the curcumin-based ligands, i.e. curcumin vs bisdemethoxycurcumin, is not straightforward. In contrast, the PTA ligand greatly enhances the activity and selectivity of ruthenium compounds in comparison to previously reported compounds.
000201194 700__ $$uUniv Camerino, Sch Pharm, I-62032 Camerino, MC, Italy$$aPettinari, Riccardo
000201194 700__ $$uUniv Camerino, Sch Sci & Technol, I-62032 Camerino, MC, Italy$$aMarchetti, Fabio
000201194 700__ $$uUniv Camerino, Sch Pharm, I-62032 Camerino, MC, Italy$$aCondello, Francesca
000201194 700__ $$uUniv Camerino, Sch Pharm, I-62032 Camerino, MC, Italy$$aPettinari, Claudio
000201194 700__ $$uUniv Camerino, Sch Pharm, I-62032 Camerino, MC, Italy$$aLupidi, Giulio
000201194 700__ $$g148592$$aScopelliti, Rosario$$0240189
000201194 700__ $$aMukhopadhyay, Suman
000201194 700__ $$g218421$$aRiedel, Tina$$0246453
000201194 700__ $$g149418$$aDyson, Paul J.$$0240015
000201194 773__ $$q3709-3715$$k14$$j33$$tOrganometallics
000201194 8560_ $$fbeatrice.marselli@epfl.ch
000201194 8564_ $$uhttps://infoscience.epfl.ch/record/201194/files/Ruthenium%28II%29-Arene%20RAPTA%20Type%20Complexes%20Containing%20Curcunnin%20and%20Bisdemethoxycurcumin%20Display%20Potent%20and%20Selective%20Anticancer%20Activity.pdf$$s1573780$$zFinal
000201194 909C0 $$xU9$$0252010$$pLCOM
000201194 909CO $$pSB$$particle$$ooai:infoscience.tind.io:201194
000201194 917Z8 $$x135992
000201194 937__ $$aEPFL-ARTICLE-201194
000201194 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000201194 980__ $$aARTICLE