000201031 001__ 201031
000201031 005__ 20190812205805.0
000201031 0247_ $$2doi$$a10.1515/pac-2014-5029
000201031 022__ $$a0033-4545
000201031 02470 $$2ISI$$a000339871300002
000201031 037__ $$aCONF
000201031 245__ $$aEnantioselective palladium(0)-catalyzed C-H arylation strategy for chiral heterocycles
000201031 260__ $$c2014$$bDe Gruyter$$aBerlin
000201031 269__ $$a2014
000201031 300__ $$a8
000201031 336__ $$aConference Papers
000201031 500__ $$aNational Licences
000201031 520__ $$aTransition-metal-catalyzed C-H functionalizations have emerged as complementary and powerful tools to access molecular complexity from widely available starting materials. Herein, we present a strategy for asymmetric intramolecular Pd(0)-catalyzed C-H functionalizations. The outlined reactivity is based on the cooperative effect between a chiral phosphorous ligand and a carboxylate base acting as a relay of chirality during the enantio-discriminating concerted metalation deprotonation step. This approach allows the enantioselective construction of a range of important semi-saturated chiral nitrogen-containing heterocycles such as indolines, tetrahydroquinolines, and dibenzazepinones.
000201031 6531_ $$aasymmetric catalysis
000201031 6531_ $$aC-H functionalization
000201031 6531_ $$acooperative effects
000201031 6531_ $$aheterocycles
000201031 6531_ $$aOMCOS-17
000201031 6531_ $$apalladium
000201031 700__ $$0246952$$g192007$$aSaget, Tanguy
000201031 700__ $$0244709$$aCramer, Nicolai$$g206338
000201031 7112_ $$dJUL 28-AUG 01, 2013$$cCO$$a17th International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS)
000201031 773__ $$j86$$tPure And Applied Chemistry$$k3$$q265-272
000201031 8564_ $$zPUBLISHER'S VERSION$$uhttps://infoscience.epfl.ch/record/201031/files/pac-2014-5029.pdf$$s859460
000201031 909C0 $$xU12340$$pLCSA$$0252404
000201031 909CO $$pconf$$pSB$$ooai:infoscience.tind.io:201031
000201031 917Z8 $$x206338
000201031 937__ $$aEPFL-CONF-201031
000201031 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000201031 980__ $$aCONF