Pattern-based sensing of aminoglycosides with fluorescent amphiphiles

A mixture of two amphiphiles with fluorescent head groups can be used as a sensing ensemble for the pattern-based analysis of aminoglycoside antibiotics. In buffered aqueous solution, the amphiphiles form a dynamic mixture of micellar aggregates. In the presence of aminoglycosides, the relative amount and the composition of the micelles is modified. The re-equilibration of the system is analyte-specific, and characteristic fluorescence spectra are obtained for different aminoglycosides. Accurate differentiation in the low micromolar concentration range can be achieved by a principal component analysis of the spectral data.


Published in:
Chemical Science, 5, 6, 2456-2460
Year:
2014
Publisher:
Cambridge, Royal Soc Chemistry
ISSN:
2041-6520
Laboratories:


Note: The status of this file is: EPFL only


 Record created 2014-06-23, last modified 2018-03-17

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