000199683 001__ 199683
000199683 005__ 20180913062532.0
000199683 0247_ $$2doi$$a10.1111/pim.12057
000199683 022__ $$a0141-9838
000199683 02470 $$2ISI$$a000331458900002
000199683 037__ $$aARTICLE
000199683 245__ $$aUnderstanding the role of antibodies in murine infections with Heligmosomoides (polygyrus) bakeri: 35 years ago, now and 35 years ahead
000199683 260__ $$aHoboken$$bWiley-Blackwell$$c2014
000199683 269__ $$a2014
000199683 300__ $$a10
000199683 336__ $$aReviews
000199683 520__ $$aThe rodent intestinal nematode H.p.bakeri has played an important role in the exploration of the host–parasite relationship of chronic nematode infections for over six decades, since the parasite was first isolated in the 1950s by Ehrenford. It soon became a popular laboratory model providing a tractable experimental system that is easy to maintain in the laboratory and far more cost-effective than other laboratory nematode–rodent model systems. Immunity to this parasite is complex, dependent on antibodies, but confounded by the parasite's potent immunosuppressive secretions that facilitate chronic survival in murine hosts. In this review, we remind readers of the state of knowledge in the 1970s, when the first volume of Parasite Immunology was published, focusing on the role of antibodies in protective immunity. We show how our understanding of the host–parasite relationship then developed over the following 35 years to date, we propose testable hypotheses for future researchers to tackle, and we speculate on how the new technologies will be applied to enable an increasingly refined understanding of the role of antibodies in host-protective immunity, and its evasion, to be achieved in the longer term.
000199683 700__ $$0243703$$aHarris, N. L.$$g196676$$uEcole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland
000199683 700__ $$aPleass, R.$$uUniv Liverpool Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England
000199683 700__ $$aBehnke, J. M.
000199683 773__ $$j36$$k3$$q115-124$$tParasite Immunology
000199683 909C0 $$0252266$$pUPHARRIS$$xU12123
000199683 909CO $$ooai:infoscience.tind.io:199683$$pSV$$preview
000199683 917Z8 $$x196676
000199683 917Z8 $$x148230
000199683 937__ $$aEPFL-REVIEW-199683
000199683 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000199683 980__ $$aREVIEW
000199683 981__ $$a196352