Mild and Phosphine-Free Iron-Catalyzed Cross-Coupling of Nonactivated Secondary Alkyl Halides with Alkynyl Grignard Reagents

A simple protocol for iron-catalyzed cross-coupling of nonactivated secondary alkyl bromides and iodides with alkynyl Grignard reagents at room temperature has been developed. A wide range of secondary alkyl halides and terminal alkynes are tolerated to afford the substituted alkynes in good yields. A slight modification of the reaction protocol also allows for cross-coupling with a variety of primary alkyl halides.


Published in:
Organic Letters, 16, 9, 2566-2569
Year:
2014
Publisher:
Washington, American Chemical Society
ISSN:
1523-7060
Laboratories:




 Record created 2014-06-16, last modified 2018-03-17

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