000199614 001__ 199614
000199614 005__ 20180317093459.0
000199614 0247_ $$2doi$$a10.1002/chem.201304991
000199614 022__ $$a0947-6539
000199614 02470 $$2ISI$$a000335197000037
000199614 037__ $$aARTICLE
000199614 245__ $$aSelenoquinones Stabilized by Ruthenium( II) Arene Complexes: Synthesis, Structure, and Cytotoxicity
000199614 260__ $$aWeinheim$$bWiley-V C H Verlag Gmbh$$c2014
000199614 269__ $$a2014
000199614 300__ $$a7
000199614 336__ $$aJournal Articles
000199614 520__ $$aA new series of monoselenoquinone and diselenoquinone complexes, [((6)-p-cymene)Ru((4)-C6R4SeE)] (R=H, E=Se (6); R=CH3, E=Se (7); R=H, E=O (8)), as well as selenolate complexes [((6)-p-cymene)Ru((5)-C6H3R2Se)][SbF6] (R=H (9); R=CH3 (10)), stabilized by arene ruthenium moieties were prepared in good yields through nucleophilic substitution reactions from dichlorinated-arene and hydroxymonochlorinated-arene ruthenium complexes [((6)-p-cymene)Ru(C6R4XCl)][SbF6](2) (R=H, X=Cl (1); R=CH3, X=Cl (2); R=H, X=OH (3)) as well as the monochlorinated complexes [((6)-p-cymene)Ru((5)-C6H3R2Cl)][SbF6](2) (R=H (4); R=CH3 (5)). The X-ray crystallographic structures of two of the compounds, [((6)-p-cymene)Ru((4)-C6Me4Se2)] (7) and [((6)-p-cymene)Ru((4)-C6H4SeO)] (8), were determined. The structures confirm the identity of the target compounds and ascertain the coordination mode of these unprecedented ruthenium complexes of selenoquinones. Furthermore, these new compounds display relevant cytotoxic properties towards human ovarian cancer cells.
000199614 6531_ $$acytotoxicity
000199614 6531_ $$api interactions
000199614 6531_ $$aruthenium
000199614 6531_ $$asandwich complexes
000199614 6531_ $$aselenoquinones
000199614 700__ $$aDubarle-Offner, Julien$$uUniv Paris 06, Univ Paris 04, IPCM, UMR 8232, F-75252 Paris 05, France
000199614 700__ $$0244594$$aClavel, Catherine M.$$g192123
000199614 700__ $$aGontard, Geoffrey$$uUniv Paris 06, Univ Paris 04, IPCM, UMR 8232, F-75252 Paris 05, France
000199614 700__ $$0240015$$aDyson, Paul J.$$g149418
000199614 700__ $$aAmouri, Hani$$uUniv Paris 06, Univ Paris 04, IPCM, UMR 8232, F-75252 Paris 05, France
000199614 773__ $$j20$$k19$$q5795-5801$$tChemistry-A European Journal
000199614 909CO $$ooai:infoscience.tind.io:199614$$particle$$pSB
000199614 909C0 $$0252010$$pLCOM$$xU9
000199614 917Z8 $$x135992
000199614 937__ $$aEPFL-ARTICLE-199614
000199614 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000199614 980__ $$aARTICLE