000199188 001__ 199188
000199188 005__ 20181203023514.0
000199188 0247_ $$2doi$$a10.3390/ma6115352
000199188 022__ $$a1996-1944
000199188 02470 $$2ISI$$a000330296400029
000199188 037__ $$aARTICLE
000199188 245__ $$aSynthesis, Molecular Structure and Cytotoxicity of Molecular Materials Based on Water Soluble Half-Sandwich Rh(III) and Ir(III) Tetranuclear Metalla-Cycles
000199188 260__ $$aBasel$$bMdpi Ag$$c2013
000199188 269__ $$a2013
000199188 300__ $$a15
000199188 336__ $$aJournal Articles
000199188 520__ $$aThe neutral dinuclear complexes [(eta(5)-C5Me5)(2)Rh-2(mu-dhnq)Cl-2] (1) and [(eta(5)-C5Me5)(2)Ir-2(mu-dhnq)Cl-2] (2) (dhnqH(2) = 5,8-dihydroxy-1,4-naphthoquinone) were obtained from the reaction of [(eta(5)-C5Me5)M(mu-Cl)Cl](2) (M = Rh, Ir) with dhnqH(2) in the presence of CH3COONa. Treatment of 1 or 2 in methanol with linear ditopic ligands L (L = pyrazine, 4,4'-bipyridine or 1,2-bis(4-pyridyl) ethylene), in the presence of AgCF3SO3, affords the corresponding tetranuclear metalla-rectangles [(eta(5)-C5Me5)(4)M-4(mu-dhnq)(2)(mu-L)(2)](4+) (L = pyrazine, M = Rh, 3; M = Ir, 4; L = 4,4'-bipyridine, M = Rh, 5; M = Ir, 6; L = 1,2-bis(4-pyridyl) ethylene, M = Rh, 7; M = Ir, 8). All complexes were isolated as their triflate salts and were fully characterized by infrared, H-1 and C-13 NMR spectroscopy, and some representative complexes by single-crystal X-ray structure analysis. The X-ray structures of 3, 5 and 6 confirm the formation of the tetranuclear metalla-cycles, and suggest that complexes 5 and 6 possess a cavity of sufficient size to encapsulate small guest molecules. In addition, the antiproliferative activity of the metalla-cycles 3-8 was evaluated against the human ovarian A2780 (cisplatin sensitive) and A2780cisR (cisplatin resistant) cancer cell lines and on non-tumorigenic human embryonic kidney HEK293 cells. All cationic tetranuclear metalla-rectangles were found to be highly cytotoxic, with IC50 values in the low micromolar range.
000199188 6531_ $$ametalla-cycles
000199188 6531_ $$ahalf-sandwich complexes
000199188 6531_ $$abioorganometallic chemistry
000199188 6531_ $$ametal-based drugs
000199188 6531_ $$ametalla-rectangles
000199188 6531_ $$aanticancer activity
000199188 700__ $$aGupta, Gajendra$$uUniv Neuchatel, Inst Chem, CH-2000 Neuchatel, Switzerland
000199188 700__ $$0245493$$aMurray, Benjamin S.$$g214821
000199188 700__ $$0240015$$aDyson, Paul J.$$g149418
000199188 700__ $$aTherrien, Bruno$$uUniv Neuchatel, Inst Chem, CH-2000 Neuchatel, Switzerland
000199188 773__ $$j6$$k11$$q5352-5366$$tMaterials
000199188 909C0 $$0252010$$pLCOM$$xU9
000199188 909CO $$ooai:infoscience.tind.io:199188$$pSB$$particle
000199188 917Z8 $$x240314
000199188 937__ $$aEPFL-ARTICLE-199188
000199188 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000199188 980__ $$aARTICLE