000198894 001__ 198894
000198894 005__ 20181203023509.0
000198894 0247_ $$2doi$$a10.1016/j.heares.2014.01.008
000198894 022__ $$a0378-5955
000198894 02470 $$2ISI$$a000334086900008
000198894 037__ $$aARTICLE
000198894 245__ $$aAuditory responses to electric and infrared neural stimulation of the rat cochlear nucleus
000198894 260__ $$bElsevier$$c2014$$aAmsterdam
000198894 269__ $$a2014
000198894 300__ $$a7
000198894 336__ $$aJournal Articles
000198894 520__ $$aIn an effort to improve the auditory brainstem implant, a prosthesis in which user outcomes are modest, we applied electric and infrared neural stimulation (INS) to the cochlear nucleus in a rat animal model. Electric stimulation evoked regions of neural activation in the inferior colliculus and short-latency, multipeaked auditory brainstem responses (ABRs). Pulsed INS, delivered to the surface of the cochlear nucleus via an optical fiber, evoked broad neural activation in the inferior colliculus. Strongest responses were recorded when the fiber was placed at lateral positions on the cochlear nucleus, close to the temporal bone. INS-evoked ABRs were multipeaked but longer in latency than those for electric stimulation; they resembled the responses to acoustic stimulation. After deafening, responses to electric stimulation persisted, whereas those to INS disappeared, consistent with a reported "optophonic" effect, a laser-induced acoustic artifact. Thus, for deaf individuals who use the auditory brainstem implant, INS alone did not appear promising as a new approach. (C) 2014 Elsevier B.V. All rights reserved.
000198894 700__ $$uUniv Manchester, Sch Med, Manchester M13 9PL, Lancs, England$$aVerma, Rohit U.
000198894 700__ $$uEcole Polytech Fed Lausanne, CH-1015 Lausanne, Switzerland$$aGuex, Amelie A.
000198894 700__ $$uMassachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA$$aHancock, Kenneth E.
000198894 700__ $$uMassachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA$$aDurakovic, Nedim
000198894 700__ $$aMckay, Colette M.
000198894 700__ $$uMassachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA$$aSlama, Michael C. C.
000198894 700__ $$uMassachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA$$aBrown, M. Christian
000198894 700__ $$uMassachusetts Eye & Ear Infirm, Eaton Peabody Lab, Boston, MA 02114 USA$$aLee, Daniel J.
000198894 773__ $$j310$$tHearing Research$$q69-75
000198894 909C0 $$xU12393$$0252424$$pLSBI
000198894 909CO $$pSTI$$particle$$ooai:infoscience.tind.io:198894
000198894 917Z8 $$x208625
000198894 937__ $$aEPFL-ARTICLE-198894
000198894 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000198894 980__ $$aARTICLE