000198771 001__ 198771
000198771 005__ 20190316235915.0
000198771 037__ $$aPOST_TALK
000198771 245__ $$aVisual backward masking deficits in schizophrenic patients are associated with polymorphisms in the nicotinic receptor alpha 7 subunit gene (CHRNA7)
000198771 269__ $$a2014
000198771 260__ $$c2014
000198771 336__ $$aPosters
000198771 520__ $$aVisual backward masking (BM) deficits are often proposed to be trait markers for schizophrenia, revealing the genetic underpinnings of the disease. Here, we show that masking deficits in the shine-through effect are associated with polymorphisms in the nicotinic receptor 7 subunit gene (CHRNA7). In the shine-through effect, two vertical bars are slightly offset in the horizontal direction. Observers indicate this offset direction. When the vernier is followed by a grating, vernier offset discrimination deteriorates for controls but much more strongly for the patients. We found these masking deficits of the patients to be strongly correlated with mutations on the rs904952 SNP and a related haplotype. The results further support the significance of CHRNA7 as an important candidate gene for schizophrenia. We propose that because of the deficient cholinergic system, the neural activity of the vernier briefly presented cannot be enhanced and is vulnerable to masking.
000198771 6531_ $$aSchizophrenia
000198771 6531_ $$aBackward Masking
000198771 6531_ $$aGenetics
000198771 700__ $$0247639$$g240796$$aShaqiri, Albulena
000198771 700__ $$0(EPFLAUTH)180397$$g180397$$aRoinishvili, Maya
000198771 700__ $$aBakanidze, George
000198771 700__ $$aChkonia, Eka
000198771 700__ $$aBrand, Andreas
000198771 700__ $$aPuls, Imke
000198771 700__ $$aHerzog, Michael$$g164642$$0243629
000198771 7112_ $$d4-5 April, 2014$$cVillars, Switzerland$$aSynapsy, 4th annual meeting
000198771 8564_ $$uhttps://infoscience.epfl.ch/record/198771/files/Shaqiri_synapsy2014.pdf$$zn/a$$s2756029$$yn/a
000198771 909C0 $$xU10987$$0252249$$pLPSY
000198771 909CO $$qGLOBAL_SET$$pSV$$ooai:infoscience.tind.io:198771$$pposter
000198771 917Z8 $$x240796
000198771 937__ $$aEPFL-POSTER-198771
000198771 973__ $$aEPFL
000198771 980__ $$aPOSTER