Phosphoric Acid Catalyzed Diastereo- and Enantioselective Synthesis of Substituted 1,3-Diaminotetralins
Dagousset, Guillaume; Erb, William; Zhu, Jieping; Masson, Géraldine
2014

Abstract

The reaction of anilines and phenylacetaldehydes in the presence of chiral phosphoric acid afforded optically active 1,2-trans, 2,3-cis 1,3-diaminotetralins in high yields with excellent diastereo- and enantioselectivities. The trans/cis product was readily isomerized to a trans/trans stereoisomer with no significant loss of enantiomeric purity.

Details

Title Phosphoric Acid Catalyzed Diastereo- and Enantioselective Synthesis of Substituted 1,3-Diaminotetralins
Author(s) Dagousset, Guillaume ; Erb, William ; Zhu, Jieping ; Masson, Géraldine
Published in Organic Letters
Pagination 4
Volume 16
Issue 9
Pages 2554-2557
Date 2014
Publisher Washington, Amer Chemical Soc
ISSN 1523-7052
DOI https://doi.org/10.1021/ol500946w
Other identifier(s) View record in Web of Science
Laboratories LSPN
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LSPN - Laboratory of synthesis and natural products
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2014-05-14

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