Balgacyclamides, Antiplasmodial Heterocyclic Peptides from Microcystis aeruguinosa EAWAG 251

The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A C, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determined by 2D-NMR methods and mass spectrometry, and the configurations were assigned after ozonolysis and hydrolysis by HPLC-MS methods using Marfey's method as well as GC-MS using authentic standards. Balgacyclamides A and B were active against Plasmodium falciparum K1 in the low micromolar range, while displaying low toxicity to rat myoblasts.


Published in:
Journal Of Natural Products, 77, 3, 557-562
Year:
2014
Publisher:
Washington, Amer Chemical Soc
ISSN:
0163-3864
Laboratories:




 Record created 2014-05-02, last modified 2018-03-17


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