000198112 001__ 198112
000198112 005__ 20181203023454.0
000198112 02470 $$2ISI
000198112 0247_ $$a10.1038/lsa.2014.3$$2doi
000198112 02470 $$a000331998400002
000198112 037__ $$aARTICLE
000198112 245__ $$aHandheld high-throughput plasmonic biosensor using computational on-chip imaging
000198112 260__ $$c2014
000198112 269__ $$a2014
000198112 300__ $$a10
000198112 336__ $$aJournal Articles
000198112 520__ $$aWe demonstrate a handheld on-chip biosensing technology that employs plasmonic microarrays coupled with a lens-free computational imaging system towards multiplexed and high-throughput screening of biomolecular interactions for point-of-care applications and resource-limited settings. This lightweight and field-portable biosensing device, weighing 60 g and 7.5 cm tall, utilizes a compact optoelectronic sensor array to record the diffraction patterns of plasmonic nanostructures under uniform illumination by a single-light emitting diode tuned to the plasmonic mode of the nanoapertures. Employing a sensitive plasmonic array design that is combined with lens-free computational imaging, we demonstrate label-free and quantitative detection of biomolecules with a protein layer thickness down to 3 nm. Integrating large-scale plasmonic microarrays, our on-chip imaging platform enables simultaneous detection of protein mono-and bilayers on the same platform over a wide range of biomolecule concentrations. In this handheld device, we also employ an iterative phase retrieval-based image reconstruction method, which offers the ability to digitally image a highly multiplexed array of sensors on the same plasmonic chip, making this approach especially suitable for high-throughput diagnostic applications in field settings.
000198112 6531_ $$acomputational imaging
000198112 6531_ $$ahigh-throughput biodetection
000198112 6531_ $$alens-free imaging
000198112 6531_ $$aon-chip sensing
000198112 6531_ $$aplasmonics
000198112 6531_ $$apoint of care diagnostics
000198112 6531_ $$atelemedicine
000198112 700__ $$uBoston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA$$aCetin, Arif E.
000198112 700__ $$uUniv Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA$$aCoskun, Ahmet F.
000198112 700__ $$uBoston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA$$aGalarreta, Betty C.
000198112 700__ $$uBoston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA$$aHuang, Min
000198112 700__ $$uUniv Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA$$aHerman, David
000198112 700__ $$uUniv Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA$$aOzcan, Aydogan
000198112 700__ $$uBoston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA$$g231181$$aAltug, Hatice$$0249978
000198112 773__ $$qe122$$j3$$tLight: Science & Applications
000198112 8560_ $$fnada.guerraoui@epfl.ch
000198112 909C0 $$xU12650$$0252567$$pBIOS
000198112 909CO $$pSTI$$particle$$ooai:infoscience.tind.io:198112
000198112 917Z8 $$x262955
000198112 937__ $$aEPFL-ARTICLE-198112
000198112 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000198112 980__ $$aARTICLE