Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel
Milosevic, Irena; Guillot, Samuel; Tadic, Marin; Duttine, Mathieu; Duguet, Etienne; Pierzchala, Katarzyna; Sienkiewicz, Andrzej; Forro, Laszlo; Saboungi, Marie-Louise
2014

Abstract

We have investigated drug loading and release from thermosensitive gel emulsions with external triggering by an alternating magnetic field (AMF) for on-demand drug delivery. Superparamagnetic iron oxide nanoparticles dispersed in gel emulsions were used to study the loading and release capabilities, with the stable nitroxide radical 2,2,6,6-tetramethyl-1-piperidinyloxy ( TEMPO) serving as the model drug. AMF activation gave similar results to temperature activation in a water bath at 37 degrees C, showing that the principal effect of the AMF is a temperature increase without burst release. These results suggest that the system could play an important role in the development of advanced drug delivery. (C) 2014 AIP Publishing LLC.

Details

Title Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel
Author(s) Milosevic, Irena ; Guillot, Samuel ; Tadic, Marin ; Duttine, Mathieu ; Duguet, Etienne ; Pierzchala, Katarzyna ; Sienkiewicz, Andrzej ; Forro, Laszlo ; Saboungi, Marie-Louise
Published in Applied Physics Letters
Pagination 5
Volume 104
Issue 4
Pages 043701
Date 2014
Publisher Melville, Amer Inst Physics
ISSN 0003-6951
DOI https://doi.org/10.1063/1.4862811
Other identifier(s) View record in Web of Science
Laboratories LPMC
LPCM
Record Appears in Scientific production and competences > SB - School of Basic Sciences > SB Archives > LPMC - Laboratory of Nanostructures and Novel Electronic Materials
Scientific production and competences > SB - School of Basic Sciences > SB Archives > LPCM - Laboratory of Thin Film Physics
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2014-04-02

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