Infoscience

Journal article

Loading and release of internally self-assembled emulsions embedded in a magnetic hydrogel

We have investigated drug loading and release from thermosensitive gel emulsions with external triggering by an alternating magnetic field (AMF) for on-demand drug delivery. Superparamagnetic iron oxide nanoparticles dispersed in gel emulsions were used to study the loading and release capabilities, with the stable nitroxide radical 2,2,6,6-tetramethyl-1-piperidinyloxy ( TEMPO) serving as the model drug. AMF activation gave similar results to temperature activation in a water bath at 37 degrees C, showing that the principal effect of the AMF is a temperature increase without burst release. These results suggest that the system could play an important role in the development of advanced drug delivery. (C) 2014 AIP Publishing LLC.

Fulltext

Related material